Systematically characterizing and prioritizing chemosensitivity related gene based on Gene Ontology and protein interaction network

Table 3 Betweenness centrality of CCRG compared with random genes

	mean of CCRG	mean of random gene	fold^**	pvalue^#
BIND	98654.40138	23213.11683	4.24994	<0.001
IntAct	149690.9051	36049.94851	4.15232	0.008
MINT	93562.07001	27842.49937	3.36058	0.015
HPRD	214315.4538	40236.19003	5.32644	<0.001
BioGRID	281377.0414	51171.666	5.49869	0.01
OPHID	252315.597	39821.59949	6.33615	<0.001

^**fold is the result of mean betweenness centrality of CCRG divided by that of random genes.
^#1000 random gene sets was selection from network, each randomization kept the number of selected genes same as that of real genes. Then for CCRG, p value was calculated over 1000 randomization.

ISSN: 1755-8794