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Table 2 Cut-points for quantitative gene scores

From: PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers

 

Score ranges

Genes/Meta-genes

Low

Intermediate

High

ESR1 (ER)

0 - 5.2

>5.2 - 7.6

>7.6 - 10

PGR (PR)

0 - 5.1

>5.1 - 7.4

>7.4 - 10

ERBB2 (HER2)§

0 - 5.6

>5.6 - 7.5

>7.5 - 10

Proliferation*

0 - 3.9

>3.9 - 5.3

>5.3 - 10

  1. high ESR1 = above median expression for Luminal A; low ESR1 = below median expression for HER2-enriched.
  2. high PGR = above median expression for Luminal A; low PGR = below median expression for Luminal B.
  3. §high ERBB2 = above median expression for HER2-enriched; low ERBB2 = below lowest quartile expression for HER2-enriched.
  4. *high Proliferation = above highest quartile expression for Luminal A; low Proliferation = below lowest quartile expression for Luminal A.