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Table 2 Cut-points for quantitative gene scores

From: PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers

  Score ranges
Genes/Meta-genes Low Intermediate High
ESR1 (ER) 0 - 5.2 >5.2 - 7.6 >7.6 - 10
PGR (PR) 0 - 5.1 >5.1 - 7.4 >7.4 - 10
ERBB2 (HER2)§ 0 - 5.6 >5.6 - 7.5 >7.5 - 10
Proliferation* 0 - 3.9 >3.9 - 5.3 >5.3 - 10
  1. high ESR1 = above median expression for Luminal A; low ESR1 = below median expression for HER2-enriched.
  2. high PGR = above median expression for Luminal A; low PGR = below median expression for Luminal B.
  3. §high ERBB2 = above median expression for HER2-enriched; low ERBB2 = below lowest quartile expression for HER2-enriched.
  4. *high Proliferation = above highest quartile expression for Luminal A; low Proliferation = below lowest quartile expression for Luminal A.