Mean depth of coverage per aortopathies gene for the enrichment methods. In A, both custom-designed gene panels (SureSelect and RainDance) yielded significantly higher average coverage per gene compared to whole-exome sequencing (SureSelect 50 Mb All Exon Capture). Bars indicate one standard deviation. In B, the fraction of exons covered to the given depth for the enrichment methods is shown. The custom-designed SureSelect gene panel yielded greater average read depths across the 294 exons for all samples versus the RainDance or whole-exome enrichments.