Figure 2From: A direct comparison of next generation sequencing enrichment methods using an aortopathy gene panel- clinical diagnostics perspective Mean exon read depth as a function of reference sequence GC content for the custom-designed gene panels. High GC content resulted in decreased exon coverage in the SureSelect enriched samples. GC content had little to no effect on exon coverage of the RainDance enriched samples, which were more prone to sporadic amplicon failure.Back to article page