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Table 1 Clinical and demographic characteristics of breast cancer patients treated with FEC/TX (n=66) and FEC/TX plus H (n=25)

From: Cell Line Derived Multi-Gene Predictor of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer: A Validation Study on US Oncology 02-103 Clinical Trial

Characteristic

66 patients treated with FEC/TX

25 patients treated with FEC/TX plus H

 

pCR No. cases (%)

RD No. cases (%)

pCR No. cases (%)

RD No. cases (%)

All patients

25 (100)

41 (100)

12(100)

13 (100)

Age in yrs

Median (range)

49 (34-69)

49 (26- 67)

50 (37-59)

49 (39-64)

Histology

Invasive ductal (IDC)

24 (96.0)

38 (92.7)

12 (100.0)

12 (92.3)

Invasive lobular (ILC)

0 (0.0)

1 (2.4)

0 (0.0)

0 (0.0)

Invasive mucinous (IMC)

0(0.0)

1 (2.4)

0(0.0)

0 (0.0)

NOS

1 (4.0)

1 (2.4)

0 (0.0)

1 (7.7)

Clinical tumor size at baseline

T1

0 (0)

1 (2.4)

0 (0.0)

0 (0.0)

T2

9 (36.0)

14 (34.1)

4 (33.3)

7 (53.8)

T3

14 (56.0)

23 (56.1)

6 (50.0)

4 (30.8)

T4

2 (8.0)

3 (7.3)

2 (16.7)

2(15.4)

Clinical node status at baseline

N0

8 (32.0)

15 (36.6)

2 (16.7)

4 (30.8)

N1

12 (48.0)

22 (53.7)

7(58.3)

4 (30.8)

N2

2 (8.0)

2 (4.9)

1 (8.3)

4 (30.8)

N3

3 (12.0)

1 (2.4)

1 (8.3)

0 (0.0)

Unkown

  

1 (8.3)

1 (7.7)

Histologic Grade

1 & 2

4 (16.0)

10 (24.4)

6 (50.0)

3 (23.1)

3

14 (56.0)

26 (63.4)

4 (33.3)

9 (69.2)

Unknown

7 (28.0)

5 (12.2)

2 (16.7)

1 (7.7)

ER status

Positive1

8 (32.0)

20 (48.8)

2 (1.7)

8 (61.5)

Negative

17 (68.0)

20 (48.8)

10 (76.9)

5 (38.5)

Unknown

0 (0.0)

1 (2.4)

  

HER-2 status

Positive 2

5 (20.0)

5 (12.2)

13 (100)

12 (92.3)

Negative

20 (80.0)

33 (80.5)

0 (0.0)

1 (7.7)

Unknown

0 (0.0)

3 (7.3)

0 (0.0)

0 (0.0)

  1. 1Cases where >10% of tumor cells stained positive for ER with immunohistochemistry were considered positive. 2Cases that showed either 3+ IHC staining or had gene copy number >2.0 were considered HER2-positive.