Cell Line Derived Multi-Gene Predictor of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer: A Validation Study on US Oncology 02-103 Clinical Trial

Table 2 Univariate and multivariate analysis results for the FEC/TX group (n=66)

Factors	Univariate logistic regression analysis		Multivariate logistic regression analysis
	OR (95% CI)	p-value	OR (95% CI)	p-value
Age	1 .00 (0.95, 1.05)	0.94	1.01 (0.94, 1.08)	0.8
ER	0.47 (0.17, 1.34)	0.16	1.16 (0.19,7.18)	0.87
PR	0.51 (0.18, 1.42)	0.20	0.87 (0.14, 5.48)	0.88
Nodal	1.27 (0.44, 3.67)	0.65	1.92 (0.46, 8.01)	0.37
T	1.10 (0.50, 2.43)	0.82	1.3 (0.49, 3.45)	0.60
Grade	1.35 (0.36, 5.09)	0.66	1.07 (0.24, 4.77)	0.92
MGP scores	0.00 (0.00, 0.2)	0.01	0.00 (0.00, 7.28)	0.15

OR: odds ratio for having pCR vs. RD; CI, confidence interval; p-value. The comparison vs. reference state for the categorical variables were ER, estrogen receptor (positive vs. negative) PR, progesterone receptor (positive vs. negative); Nodal (positive vs. negative); T (Tumor size); Grade (grade 3 vs. 2) and MGP scores.

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