Table 6 Distribution of the tumors within the immunohistochemistry intrinsic classes according to SBR grade and array CGH-based genomic characteristics
All n = 135 (%) | Luminal A n = 83 | Luminal B n = 33 | HER2-enriched n = 10 | Basal n = 7 | Unclassified n = 2 | |
|---|---|---|---|---|---|---|
SBR Grade | ||||||
1 | 25 (18) | 24 (29) | 0 | 0 | 1 (14) | 0 |
2 | 71 (53) | 53 (64) | 16 (49) | 1 (10) | 0 | 1 |
3 | 39 (29) | 6 ( 7) | 17 (52) | 9 (90) | 6 (86) | 1 |
Array CGH clusters | ||||||
a | 34 (25) | 17 (20) | 5 (15) | 5 (50) | 6 (86) | 1 |
b | 25 (18) | 20 (24) | 3 ( 9) | 2 (20) | 0 | 0 |
c | 16 (12) | 7 ( 8) | 8 (24) | 0 | 0 | 1 |
d | 13 (10) | 9 (11) | 3 ( 9) | 1 (10) | 0 | 0 |
e | 35 (26) | 23 (28) | 11 (33) | 1 (10) | 0 | 0 |
f | 12 ( 9) | 7 ( 8) | 3 ( 9) | 1 (10) | 1 (14) | 0 |
Nb. of amplicons | ||||||
0 | 71 (53) | 56 (67) | 7 (21) | 1 (10) | 6 (86) | 1 |
≥1 | 64 (47) | 27 (33) | 26 (79) | 9 (90) | 1 (14) | 1 |
Range | 1–17 | 1–10 | 1–17 | 1–11 | NA | 1 |
Mean | 4.9 | 3.6 | 5.6 | 4.9 | 9 | 1 |
G2I classes | ||||||
1 | 19 (14) | 16 (19) | 2 ( 6) | 1 (10) | 0 | 0 |
2 | 88 (65) | 55 (66) | 19 (58) | 6 (60) | 6 (86) | 2 |
3 | 28 (21) | 12 (15) | 12 (36) | 3 (30) | 1 (14) | 0 |