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Table 6 Distribution of the tumors within the immunohistochemistry intrinsic classes according to SBR grade and array CGH-based genomic characteristics

From: An array CGH based genomic instability index (G2I) is predictive of clinical outcome in breast cancer and reveals a subset of tumors without lymph node involvement but with poor prognosis

  All n = 135 (%) Luminal A n = 83 Luminal B n = 33 HER2-enriched n = 10 Basal n = 7 Unclassified n = 2
SBR Grade
1 25 (18) 24 (29) 0 0 1 (14) 0
2 71 (53) 53 (64) 16 (49) 1 (10) 0 1
3 39 (29) 6 ( 7) 17 (52) 9 (90) 6 (86) 1
Array CGH clusters
a 34 (25) 17 (20) 5 (15) 5 (50) 6 (86) 1
b 25 (18) 20 (24) 3 ( 9) 2 (20) 0 0
c 16 (12) 7 ( 8) 8 (24) 0 0 1
d 13 (10) 9 (11) 3 ( 9) 1 (10) 0 0
e 35 (26) 23 (28) 11 (33) 1 (10) 0 0
f 12 ( 9) 7 ( 8) 3 ( 9) 1 (10) 1 (14) 0
Nb. of amplicons
0 71 (53) 56 (67) 7 (21) 1 (10) 6 (86) 1
≥1 64 (47) 27 (33) 26 (79) 9 (90) 1 (14) 1
Range 1–17 1–10 1–17 1–11 NA 1
Mean 4.9 3.6 5.6 4.9 9 1
G2I classes
1 19 (14) 16 (19) 2 ( 6) 1 (10) 0 0
2 88 (65) 55 (66) 19 (58) 6 (60) 6 (86) 2
3 28 (21) 12 (15) 12 (36) 3 (30) 1 (14) 0