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Table 7 p53 alterations

From: An array CGH based genomic instability index (G2I) is predictive of clinical outcome in breast cancer and reveals a subset of tumors without lymph node involvement but with poor prognosis

IHC status of p53(a) Mutation status of TP53 (b) Type of TP53 mutation(c) All (%)
  - + ms tm  
- 96 11 1 10 107 (80)
+ 7 20 19 1 27 (20)
All (%) 103 (77) 31 (23) 20 (15) 11 (8) 134 (100)
  1. (a) +: Immunohistochemical detection of p53 accumulation in at least 10% of tumor cells, -: no p53 signal; (b) +: detection of a mutation of TP53 (listed in Additional file 2), -: wild type TP53; (c) ms: missense mutation, tm: truncated mutation (frameshift or nonsense).