An array CGH based genomic instability index (G2I) is predictive of clinical outcome in breast cancer and reveals a subset of tumors without lymph node involvement but with poor prognosis

Table 7 p53 alterations

IHC status of p53^(a)	Mutation status of *TP53* ^(b)		Type of TP53 mutation^(c)		All (%)
	-	+	ms	tm
-	96	11	1	10	107 (80)
⁺	7	20	19	1	27 (20)
All (%)	103 (77)	31 (23)	20 (15)	11 (8)	134 (100)

^(a) +: Immunohistochemical detection of p53 accumulation in at least 10% of tumor cells, -: no p53 signal; ^(b) +: detection of a mutation of TP53 (listed in Additional file 2), -: wild type TP53; ^(c) ms: missense mutation, tm: truncated mutation (frameshift or nonsense).

ISSN: 1755-8794