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Table 2 Top 36 multi-exon genes that have significant alternative exon usage associated with glioblastoma multiforme survival

From: Identification and characterization of alternative exon usage linked glioblastoma multiforme survival

Gene Symbol

Estimate1

SE2

P-value AEU3

Fold change4

Exon Count5

Literature6

Ttn

0.0007

0.0001

4.2E-38

0.9993

340

[28]G

Smg1

0.0017

0.0002

2.0E-24

1.0001

209

[29]AS

Neb

0.0007

0.0001

3.2E-21

0.9973

180

[30, 31]C, AS

Pkd1

0.0010

0.0001

2.0E-19

1.0018

163

[32]G, AS

Herc2p2

0.0008

0.0001

2.3E-19

1.0012

163

NA

Syne1

0.0018

0.0002

3.0E-18

0.9984

152

[9]G

Snrpn

0.0018

0.0002

3.8E-18

1.0020

151

[33, 34]G, AS

Pde4dip

0.0016

0.0002

1.3E-17

0.9993

146

[35, 36]G, AS

Golga8c

0.0031

0.0004

4.2E-17

1.0005

141

NA

Sspo

0.0009

0.0001

1.2E-16

1.0003

137

NA

Ankrd36

0.0026

0.0003

1.3E-16

1.0018

137

NA

Tbc1d3

0.0008

0.0001

2.4E-16

1.0026

135

[37]C

Flj45340

0.0018

0.0002

5.5E-16

1.0007

131

NA

Anapc1

0.0009

0.0001

5.8E-15

0.9990

122

[38, 39]C, AS

Syne2

0.0012

0.0002

6.2E-15

1.0017

115

[40]C, AS

Nbpf10

0.0035

0.0005

1.3E-14

0.9992

118

[41]C, AS

Muc19

0.0015

0.0002

1.4E-14

1.0001

118

[42]C, AS

Obscn

0.0006

0.0001

1.5E-14

0.9999

118

[28, 43]G, AS

Npipl3

0.0019

0.0003

4.1E-14

1.0014

114

NA

Dst

0.0013

0.0002

9.4E-14

0.9997

111

[44, 45]G, AS

Col7a1

0.0011

0.0001

1.4E-13

1.0001

109

[46, 47]C, AS

Ubr4

0.0011

0.0001

1.4E-13

0.9994

109

[48, 49]C, AS

Hmcn1

0.0006

0.0001

2.0E-13

0.9975

109

[50]C, AS

Ryr2

0.0011

0.0001

2.7E-13

0.9974

107

[51, 52]G, AS

Macf1

0.0011

0.0002

3.1E-13

0.9975

106

[53, 54]G, AS

Mdn1

0.0006

0.0001

3.5E-13

0.9993

106

NA

Col4a5

0.0008

0.0001

3.5E-13

0.9992

106

[55, 56]C, AS

Ryr1

0.0007

0.0001

4.2E-13

0.9998

105

[31, 57, 58]G, AS

Golga6l5

0.0013

0.0002

5.2E-13

1.0021

104

NA

Ryr3

0.0009

0.0001

1.3E-12

0.9962

102

[59]C, AS

Dnah14

0.0007

0.0001

2.0E-12

0.9990

99

NA

Herc2

0.0006

0.0001

3.1E-12

1.0003

97

[60]AS

Dnah8

0.0005

0.0001

4.7E-12

0.9997

96

NA

Nomo1

0.0007

0.0001

4.9E-12

0.9996

95

NA

Gpr98

0.0016

0.0002

5.9E-12

0.9948

95

[61]C, AS

Golga6a

0.0017

0.0002

7.8E-12

1.0009

93

NA

  1. 1Estimate: exon-survival interaction variance indicator of alternative exon usage.
  2. 2SE: standard error of the estimate.
  3. 3P-value AEU: unadjusted P-value of alternative exon usage or exon-dependent association between expression and glioblastoma multiforme survival.
  4. 4Fold change: fold change in average exon expression per additional survival month.
  5. 5Exon Count: number of exons in the gene.
  6. 6Literature: review of studies that reported associations of the gene with cancers:
  7. G: reported association of gene with glioblastoma multiforme,
  8. C: reported association of gene with cancer other than glioblastoma multiforme,
  9. AS: identification of different variants due to alternative splicing (AS) event,
  10. NA: not available.
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BMC Medical Genomics

ISSN: 1755-8794

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