Identification and characterization of alternative exon usage linked glioblastoma multiforme survival

BMC Medical Genomics

Table 6 Ten most significant GO biological processes from the gene set enrichment analysis of the genome

GO Identifier	GO Biological Process	Over-Expressed Gene¹	Under-Expressed Genes²	Log Odds Ratio³	FDR P-value⁴
GO:0046907	intracellular transport	357	560	−0.7338	3.79E-24
GO:0034613	cellular protein localization	245	433	−0.8490	4.78E-24
GO:0043067	regulation of programmed cell death	351	490	−0.6110	1.68E-15
GO:0016192	vesicle-mediated transport	271	400	−0.6639	1.16E-14
GO:0006629	lipid metabolic process	424	538	−0.5148	1.30E-12
GO:0044265	cellular macromolecule catabolic process	373	485	−0.5379	2.10E-12
GO:0044255	cellular lipid metabolic process	346	457	−0.5528	2.41E-12
GO:0050793	regulation of developmental process	442	549	−0.4932	4.27E-12
GO:0007049	cell cycle	418	522	−0.4978	1.11E-11
GO:0009966	regulation of signal transduction	414	509	−0.4812	9.93E-11

¹Over-Expressed Genes: number of genes that have a positive association between expression and glioblastoma multiforme survival.
²Under-Expressed Genes: number of genes that have a negative association between expression and glioblastoma multiforme survival.
³Log Odds Ratio: indicates whether the category is more enriched among the genes that have a positive association between expression and survival relative to the enrichment among the genes that have a negative association between expression and glioblastoma survival (positive log_e odds ratio) or vice versa (negative log_e odds ratio). Extreme values indicate higher difference in the enrichment percentages between the positive and negative association groups meanwhile values close to zero indicate similar enrichment percentages between positive and negative association groups.
⁴FDR-adjusted P-value: False discovery rate adjusted P-value of the log odds ratio test.

ISSN: 1755-8794