Identification and characterization of alternative exon usage linked glioblastoma multiforme survival

BMC Medical Genomics

Table 7 Ten most significant GO molecular functions from the gene set enrichment analysis

GO Identifier	GO Molecular Function	Over-Expressed Gene¹	Under-Expressed Genes²	Log Odds Ratio³	FDR P-value⁴
GO:0000287	magnesium ion binding	196	300	−0.6962	3.23E-11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus containing anhydrides	419	521	−0.4933	5.21E-11
GO:0016462	pyrophosphatase activity	417	520	−0.4962	5.21E-11
GO:0016817	hydrolase activity, acting on acid anhydrides	428	527	−0.4834	9.62E-11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	393	475	−0.4624	5.64E-09
GO:0016301	kinase activity	421	501	−0.4473	5.64E-09
GO:0016788	hydrolase activity, acting on ester bonds	349	429	−0.4781	9.84E-09
GO:0003723	RNA binding	357	437	−0.4741	9.84E-09
GO:0030695	GTPase regulator activity	193	260	−0.5651	4.10E-07
GO:0016874	ligase activity	205	272	−0.5501	4.10E-07

¹Over-Expressed Genes: number of genes that have a positive association between expression and glioblastoma multiforme survival.
²Under-Expressed Genes: number of genes that have a negative association between expression and glioblastoma multiforme survival.
³Log Odds Ratio: indicates whether the category is more enriched among the genes that have a positive association between expression and survival relative to the enrichment among the genes that have a negative association between expression and glioblastoma survival (positive log_e odds ratio) or vice versa (negative log_e odds ratio). Extreme values indicate higher difference in the enrichment percentages between the positive and negative association groups meanwhile values close to zero indicate similar enrichment percentages between positive and negative association groups.
⁴FDR-adjusted P-value: False discovery rate adjusted P-value of the log odds ratio test.

ISSN: 1755-8794