Figure 1

Finnish twin WGCNA results indicate that the blue module is associated with serum TG levels. Each row represents a module (labeled by color), and each column represents a trait. The value at the top of each square represents the correlation coefficient between the module eigengene and the trait with the correlation p-value in parentheses. The red color represents a positive correlation between the module eigengene and trait, and the green color represents a negative correlation. The number of gene expression probes present in each module and the percent of probes correlated with TGs (p<0.05, Pearson correlation) are listed in parenthesis next to the module color. To prevent potential confounding factors influencing expression values, gene expression values were corrected for age, sex, and twin relatedness using the Microarray Quality Control Pipeline as described previously [10]. TG values were log transformed and corrected for age, sex, disconcordant BMI status, and BMI using stepwise linear regression. BMI values were corrected for age, sex, disconcordant BMI status, and TG using stepwise linear regression. Genes that could not be clustered into one of the modules were assigned to the grey module, thus grey denotes background genes outside of modules. The blue module associated with TGs passed the Bonferroni correction for the 16 statistical tests performed (8 modules, 2 traits); the Bonferroni p-value cut-off = 3.1 x 10^-3.