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Table 3 Allele frequencies in COPD and control subjects for SNPs

From: Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case–control study

SNP Allele Control (n,%) Case (n,%) χ 2 P value OR OR(95%CI) P (Bonferroni) Adjusted P value Adjusted OR Adjusted OR(95%CI) Adjusted P (Bonferroni)
rs1059823 G 139(33) 222(34) 0.0181 0.8929 1.01 0.79-1.32 67.8604 0.8290 0.97 0.74-1.27 63.0040
  A 283(67) 440(66)          
rs1205 C 168(40) 308(47) 5.2168 0.0223 1.34 1.04-1.71 1.6948 0.0030 1.48 1.14-1.91 0.2280
  T 252(60) 346(53)          
rs17019336 A 136(32) 242(37) 2.1770 0.1401 1.21 0.94-1.57 10.6476 0.0670 1.28 0.98-1.68 5.0920
  T 284(68) 416(63)          
rs1799964 T 333(79) 519(79) 0.0008 0.9772 1.00 0.74-1.36 74.2672 0.8140 0.96 0.71-1.31 61.8640
  C 87(21) 135(21)          
rs1800610 T 71(17) 112(17) 0.0117 0.9137 1.02 0.74-1.41 69.4412 0.9007 0.98 0.70-1.38 68.4532
  C 355(83) 550(83)          
rs2077464 T 271(65) 420(66) 0.1909 0.6621 1.06 0.82-1.37 50.3196 0.8230 1.03 0.79-1.35 62.5480
  C 149(35) 218(34)          
rs2236302 C 369(88) 584(89) 0.2011 0.6539 1.09 0.75-1.59 49.6964 0.4140 1.18 0.80-1.75 31.4640
  G 51(12) 74(11)          
rs2292566 A 125(30) 209(32) 0.4800 0.4884 1.10 0.84-1.43 37.1184 0.7630 1.04 0.79-1.38 57.9880
  G 295(70) 449(68)          
rs2353397 C 123(29) 382(58) 83.3798 6.8×10 -20 3.29 2.54-4.28 5.2×10 -18 <0.0001 2.16 1.66-2.81 <0.0001
  T 297(71) 280(42)          
rs25882 T 147(35) 240(36) 0.2421 0.6227 1.07 0.83-1.38 47.3252 0.4650 1.10 0.85-1.44 35.3400
  C 273(65) 418(64)          
rs2808630 C 66(16) 119(18) 1.0136 0.3140 1.18 0.85-1.65 23.8640 0.2120 0.86 0.69-1.09 16.1120
  T 354(84) 539(82)          
rs3749893 A 286(67) 454(69) 0.6232 0.4299 1.11 0.86-1.44 32.6724 0.4510 1.11 0.84-1.46 34.2760
  G 140(33) 200(31)          
rs4987835 A 236(56) 382(60) 1.7185 0.1899 1.19 0.92-1.51 14.4324 0.2950 1.15 0.88-1.49 22.4200
  G 184(44) 252(40)          
rs709932 A 73(17) 131(20) 1.2714 0.2595 1.20 0.87-1.65 19.7220 0.2860 1.19 0.86-1.65 21.7360
  G 347(83) 519(80)          
rs7217852 A 273(65) 434(66) 0.0652 0.7985 1.03 0.80-1.34 60.6860 0.8460 1.03 0.79-1.34 64.2960
  G 147(35) 226(34)          
rs7776375 A 270(63) 438(66) 0.8832 0.3473 1.13 0.88-1.46 26.3948 0.2570 1.17 0.89-1.52 19.5320
  G 156(37) 224(34)          
rs10069690 C 331(80) 520(81) 0.0264 0.8709 1.03 0.75-1.40 66.1884 0.6480 1.08 0.78-1.48 49.2480
  T 81(20) 124(19)          
rs1051740 T 247(60) 403(61) 0.0424 0.8369 1.03 0.79-1.32 63.6044 0.8910 1.02 0.79-1.32 67.7160
  C 163(40) 259(39)          
rs11155242 A 372(90) 604(91) 0.5784 0.4469 1.18 0.77-1.79 33.9644 0.2560 1.28 0.83-1.94 19.4560
  C 42(10) 58(9)          
rs1295685 T 118(29) 221(33) 2.8124 0.0935 1.26 0.96-1.64 7.1060 0.1730 1.21 0.92-1.60 13.1480
  C 296(71) 441(67)          
rs1435867 C 55(13) 90(14) 0.0200 0.8877 1.03 0.72-1.47 67.4652 0.5300 0.89 0.62-1.29 40.5080
  T 355(87) 566(86)          
rs16909898 G 33(8) 54(8) 0.0101 0.9200 1.02 0.65-1.61 69.9200 0.3140 0.79 0.50-1.25 23.8640
  A 379(92) 606(92)          
rs1881457 A 308(74) 495(75) 0.0726 0.7876 1.04 0.78-1.38 59.8576 0.9120 1.02 0.76-1.36 69.3120
  C 108(26) 167(25)          
rs2241718 T 114(28) 206(31) 1.4433 0.2296 1.18 0.90-1.55 17.4496 0.2930 1.16 0.88-1.53 22.2680
  C 298(72) 456(69)          
rs2277027 C 64(15) 106(16) 0.0586 0.8088 1.04 0.74-1.46 61.4688 0.8350 0.96 0.68-1.36 63.4600
  A 350(85) 556(84)          
rs2736100 T 231(57) 368(58) 0.1539 0.6948 1.05 0.82-1.35 52.8048 0.6340 1.06 0.82-1.38 48.1840
  G 173(43) 262(42)          
rs35621 C 305(74) 499(75) 0.1317 0.7167 1.05 0.79-1.40 54.4692 0.3480 1.15 0.86-1.54 26.4480
  T 105(26) 163(25)          
rs3995090 C 288(70) 461(71) 0.1521 0.6965 1.06 0.80-1.39 52.9340 0.4200 1.12 0.84-1.48 31.9200
  A 122(30) 185(29)          
rs4246742 A 244(60) 429(65) 3.0339 0.0815 1.25 0.97-1.61 6.1940 0.0510 1.32 1.01-1.71 3.8760
  T 166(40) 233(35)          
rs6712954 G 321(78) 545(82) 3.1679 0.0751 1.32 0.97-1.79 5.7076 0.0560 1.38 1.01-1.89 4.2560
  A 91(22) 117(18)          
rs829259 A 137(33) 233(35) 0.4250 0.5145 1.09 0.84-1.41 39.1020 0.9300 1.01 0.77-1.32 70.6800
  T 275(67) 429(65)          
rs10075508 T 69(16) 108(17) 0.0253 0.8736 1.03 0.74-1.43 66.3936 0.9070 1.02 0.72-1.44 68.9320
  C 357(84) 544(83)          
rs10512249 T 33(8) 52(8) 0.0606 0.8056 1.06 0.67-1.67 61.2256 0.4950 1.16 0.75-1.80 37.6200
  C 383(92) 570(92)          
rs12899618 G 370(89) 579(89) 0.0806 0.7765 1.06 0.72-1.56 59.0140 0.6010 1.11 0.75-1.65 45.6760
  A 48(11) 71(11)          
rs13706 G 272(65) 427(65) 0.0598 0.8068 1.03 0.80-1.34 61.3168 0.8300 0.97 0.75-1.27 63.0800
  A 148(35) 225(35)          
rs1531697 A 255(61) 411(63) 0.5370 0.4637 1.10 0.85-1.41 35.2412 0.4750 1.10 0.85-1.43 36.1000
  T 163(39) 239(37)          
rs1800925 T 62(15) 105(17) 0.8620 0.3531 1.18 0.84-1.66 26.8356 0.1000 1.32 0.94-1.85 7.6000
  C 352(85) 507(83)          
rs3024791 G 388(93) 616(95) 1.5299 0.2161 1.39 0.82-2.34 16.4236 0.3820 1.25 0.76-2.06 29.0320
  A 28(7) 32(5)          
rs6537302 A 310(75) 480(77) 0.7206 0.3959 1.13 0.85-1.51 30.0884 0.9110 1.10 0.76-1.36 69.2360
  T 104(25) 142(23)          
rs6555465 G 195(46) 310(48) 0.4399 0.5072 1.09 0.85-1.39 38.5472 0.5010 1.09 0.85-1.41 38.0760
  A 231(54) 338(52)          
rs673400 C 178(43) 278(43) 0.0062 0.9371 1.01 0.79-1.30 71.2196 0.9280 0.99 0.76-1.28 70.5280
  G 238(57) 368(57)          
rs6889822 G 268(64) 417(65) 0.0594 0.8073 1.03 0.80-1.34 61.3548 0.5000 1.10 0.84-1.43 38.0000
  A 148(36) 223(35)          
rs8004738 G 184(44) 275(44) 0.0092 0.9236 1.01 0.79-1.30 70.1936 0.6650 1.01 0.82-1.37 50.5400
  A 232(56) 351(56)          
rs1003349 G 238(57) 392(60) 0.8897 0.3456 1.13 0.88-1.45 26.2656 0.2340 1.17 0.90-1.51 17.7840
  T 178(43) 260(40)          
rs1032295 T 320(75) 523(80) 3.1870 0.0742 1.30 0.97-1.74 5.6392 0.1130 1.28 0.94-1.73 8.5880
  G 106(25) 133(20)          
rs1042522 C 184(44) 304(47) 0.8170 0.3660 1.12 0.88-1.43 27.8160 0.4090 1.11 0.86-1.44 31.0840
  G 236(56) 348(53)          
rs1052443 C 281(67) 457(71) 1.7602 0.1846 1.20 0.92-1.56 14.0296 0.1610 1.22 0.93-1.60 12.2360
  A 139(33) 189(29)          
rs12504628 T 305(72) 475(72) 0.0847 0.7710 1.04 0.79-1.37 58.5960 0.9810 1.04 0.76-1.33 74.5560
  C 121(28) 181(28)          
rs1695 G 72(17) 126(19) 0.6673 0.4140 1.14 0.83-1.57 31.4640 0.4650 1.13 0.82-1.57 35.3400
  A 346(83) 530(81)          
rs1800469 C 182(44) 315(48) 2.1252 0.1449 1.20 0.94-1.54 11.0124 0.2010 1.74 1.35-2.27 15.2760
  T 234(56) 337(52)          
rs20541 T 118(28) 228(35) 5.3633 0.0206 1.37 1.05-1.79 1.5656 0.0280 1.36 1.04-1.80 2.1280
  C 302(72) 426(65)          
rs2070600 G 312(73) 529(81) 8.1712 0.0043 1.52 1.14-2.03 0.3268 0.0130 1.47 1.08-1.98 0.9880
  A 114(27) 127(19)          
rs2853209 A 191(45) 305(47) 0.1953 0.6586 1.06 0.83-1.35 50.0536 0.9890 0.10 0.77-1.29 75.1640
  T 231(55) 349(53)          
rs4073 A 185(44) 300(46) 0.5198 0.4709 1.10 0.86-1.40 35.7884 0.2530 1.16 0.90-1.50 19.2280
  T 235(56) 348(54)          
rs6937121 T 254(60) 423(65) 2.1263 0.1448 1.21 0.94-1.56 11.0048 0.1720 1.20 0.92-1.56 13.0720
  G 166(40) 229(35)          
rs6957 G 150(36) 241(37) 0.0802 0.7771 1.04 0.80-1.34 59.0596 0.6830 1.06 0.81-1.38 51.9080
  A 268(64) 415(63)          
rs1051730 C 403(97) 641(97) 0.2343 0.6284 1.20 0.57-2.52 47.3252 0.6480 1.17 0.60-2.29 49.2480
  T 11(3) 21(3)          
rs10947233 G 299(72) 526(79) 7.4524 0.0063 1.49 1.12-1.98 0.4788 0.0060 1.51 1.12-2.03 0.4560
  T 115(28) 136(21)          
rs11106030 C 355(85) 560(85) 0.0013 0.9716 1.01 0.71-1.42 73.8416 0.7030 1.07 0.75-1.52 53.4280
  A 63(15) 100(15)          
rs1130864 T 23(6) 43(7) 0.6081 0.4355 1.23 0.73-2.07 33.0980 0.3890 1.24 0.77-2.00 29.5640
  C 389(94) 591(93)          
rs1800629 G 379(90) 627(95) 7.8793 0.0050 1.94 1.21-3.10 0.3800 0.0060 1.97 1.21-3.21 0.4560
  A 41(10) 35(5)          
rs2241712 A 188(45) 342(52) 3.9820 0.0460 1.28 1.00-1.64 3.4960 0.0498 1.24 0.96-1.59 3.7848
  G 226(55) 320(48)          
rs2280090 G 395(94) 629(95) 0.9844 0.3211 1.30 0.77-2.20 24.4036 0.4640 1.22 0.72-2.06 35.2640
  A 27(6) 33(5)          
rs2395730 A 119(28) 209(32) 1.3886 0.2386 1.17 0.90-1.54 18.1336 0.0850 1.28 0.97-1.69 6.4600
  C 303(72) 453(68)          
rs2736118 A 397(94) 630(95) 0.6150 0.4329 1.24 0.72-2.12 32.9004 0.2850 1.36 0.78-2.37 21.6600
  G 25(6) 32(5)          
rs2736122 C 388(94) 632(95) 1.5783 0.2090 1.41 0.82-2.42 15.884 0.0510 1.77 1.02-3.07 3.8760
  T 26(6) 30(5)          
rs3817928 A 370(89) 596(90) 0.1202 0.7288 1.07 0.72-1.61 55.3888 0.4410 1.17 0.78-1.76 33.5160
  G 44(11) 66(10)          
rs584367 T 91(22) 152(23) 0.1399 0.7083 1.06 0.79-1.42 53.8308 0.8590 1.03 0.76-1.39 65.2840
  C 323(78) 510(77)          
rs1042714 C 374(90) 607(92) 1.1947 0.2744 1.27 0.83-1.96 20.8544 0.1440 1.39 0.90-2.14 10.9440
  G 40(10) 374(90)          
rs13147758 A 283(69) 464(71) 0.8780 0.3487 1.14 0.87-1.49 26.5012 0.3840 1.13 0.86-1.49 29.1840
  G 129(31) 186(29)          
rs1422795 G 61(15) 108(16) 0.5395 0.4626 1.14 0.81-1.60 35.1576 0.8690 1.03 0.73-1.46 66.0440
  A 353(85) 550(84)          
rs1800796 C 293(71) 473(72) 0.1539 0.6948 1.06 0.80-1.39 52.8048 0.8250 1.03 0.78-1.36 62.7000
  G 121(29) 185(28)          
rs2236307 C 169(41) 286(43) 0.7270 0.3938 1.11 0.87-1.43 29.9288 0.4150 1.11 0.86-1.44 31.5400
  T 245(59) 372(57)          
rs2280091 A 383(93) 611(93) 0.1518 0.6968 1.10 0.68-1.77 52.9568 0.5020 1.17 0.74-1.87 38.1520
  G 31(7) 45(7)          
rs2853676 G 335(81) 544(83) 0.4538 0.5005 1.12 0.81-1.54 38.0380 0.2770 1.20 0.86-1.67 21.0520
  A 77(19) 112(17)          
rs868966 A 205(50) 337(51) 0.2934 0.5880 1.07 0.84-1.37 44.6880 0.7890 1.04 0.80-1.34 59.9640
  G 209(50) 321(49)          
  1. Chi-square test and logistic analysis were used.
  2. Logistic analysis was adjusted by potential confounders including age, gender, smoking history.
  3. The p value with bold letters indicate those allele frequencies with significant differences between COPD and controls.