TY - JOUR AU - Hiura, Hitoshi AU - Okae, Hiroaki AU - Kobayash, Hisato AU - Miyauchi, Naoko AU - Sato, Fumi AU - Sato, Akiko AU - Suzuki, Fumihiko AU - Nagase, Satoru AU - Sugawara, Junichi AU - Nakai, Kunihiko AU - Yaegashi, Nobuo AU - Arima, Takahiro PY - 2012 DA - 2012/03/26 TI - High-throughput detection of aberrant imprint methylation in the ovarian cancer by the bisulphite PCR-Luminex method JO - BMC Medical Genomics SP - 8 VL - 5 IS - 1 AB - Aberrant DNA methylation leads to loss of heterozygosity (LOH) or loss of imprinting (LOI) as the first hit during human carcinogenesis. Recently we developed a new high-throughput, high-resolution DNA methylation analysis method, bisulphite PCR-Luminex (BPL), using sperm DNA and demonstrated the effectiveness of this novel approach in rapidly identifying methylation errors. SN - 1755-8794 UR - https://doi.org/10.1186/1755-8794-5-8 DO - 10.1186/1755-8794-5-8 ID - Hiura2012 ER -