Table 5 Ten most down-regulated pathways in insulin-resistant compared to insulin-sensitive group during euglycemic hyperinsulinemic conditions
GO category | Pathway name | Nominal p | Permuted p |
|---|---|---|---|
GO:0005746 | mitochondrial respiratory chain | 9.7E-06 | 0.0002 |
GO:0044429 | mitochondrial part | 1.3E-05 | 0.001 |
GO:0022900 | electron transport chain | 1.6E-05 | 0.0002 |
GO:0050890 | cognition | 2.6E-05 | 0.0005 |
GO:0016651 | oxidoreductase activity, acting on NADH or NADPH | 3.9E-05 | 0.0002 |
GO:0005759 | mitochondrial matrix | 4.9E-05 | 0.0008 |
GO:0031349 | positive regulation of defense response | 7.3E-05 | 0.0008 |
GO:0022891 | substrate-specific transmembrane transporter activity | 8.9E-05 | 0.0022 |
GO:0003954 | NADH dehydrogenase activity | 1.0E-04 | 0.0023 |
GO:0055114 | oxidation reduction | 1.1E-04 | 0.0037 |