DNA methylation at FBXL5, SCMH1 and CACYBP promoters correlates with KDM5C/KDM5D dosage. Boxplots show DNA methylation levels for CpG sites within the FBXL5, SCMH1 and CACYBP promoters in blood in 7 group of samples with different dosage of KDM5C/KDM5D. CpG numbering corresponds to Figures 4D, 6D and 7D. CACYBP CpG#2 boxplot is not shown, as no correlation with KDM5C/KDM5D dosage was found for this site. The Y axis is % of DNA methylation. The X axis shows groups of samples, numbered from 1 to 7. Information for each group regarding sex chromosome constitution, X-chromosome inactivation (XCI, Xa is active and Xi is inactive X-chromosome respectively), presence/absence of KDM5C mutation, functional KDM5C/KDM5D dosage, and number of samples is shown in the table beside the graph.