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Table 2 Pathways enriched with driver genes that are associated to over- and under-expressed pathways in GBMs

From: Genome-wide associations of signaling pathways in glioblastoma multiforme

Over-expressed pathways
Enriched pathways P Driver genes
ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0.001 PIK3CA KRAS EGFR GAB1
VEGFR1_PATHWAY 0.002 PGF PIK3CA NOS3 GAB1
PDGFRBPATHWAY 0.003 PTEN SHB GAB1 PTPRJ PIK3CA
TCPTP_PATHWAY 0.004 HGF PIK3CA EGFR GAB1
ERBB1_DOWNSTREAM_PATHWAY 0.005 PIK3CA EGFR GAB1 BRAF KSR1 KRAS
IL2_STAT5PATHWAY 0.019 IL2RA CDK6 PIK3CA
PI3KPLCTRKPATHWAY 0.020 PIK3CA GAB1 KRAS
ERBB1_INTERNALIZATION_PATHWAY 0.022 PIK3CA EGFR KRAS
TRKRPATHWAY 0.023 PIK3CA GAB1 NTRK2 KRAS
RET_PATHWAY 0.038 PIK3CA RET GAB1
FASPATHWAY 0.038 PIK3CA CASP3 FAS
VEGFR1_2_PATHWAY 0.039 PIK3CA SHB NOS3 GAB1
ER_NONGENOMIC_PATHWAY 0.042 PIK3CA NOS3 KRAS
TCRRASPATHWAY 0.045 BRAF KRAS
Under-expressed pathways
Enriched pathways P Driver genes
ERBB2ERBB3PATHWAY 0.005 PIK3R3 MAPK10 FRAP1 KRAS
TCPTP_PATHWAY 0.006 HGF PIK3R3 EGF KDR
ET_EGFRPATHWAY 0.008 FRAP1 EGF
ERBB1_DOWNSTREAM_PATHWAY 0.009 FRAP1 PIK3R3 EPS8 KSR1 EGF KRAS
IL2_1PATHWAY 0.017 IL2RA IL2 PRKCB1 KRAS
ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0.019 PIK3R3 EGF KRAS
ERBB1_INTERNALIZATION_PATHWAY 0.027 PIK3R3 EGF KRAS
TCRRASPATHWAY 0.027 PRKCB1 KRAS
CD8TCRDOWNSTREAMPATHWAY 0.033 IL2RA IL2 PRKCB1 KRAS
CXCR3PATHWAY 0.038 PIK3R3 FRAP1 KRAS
IL2_PI3KPATHWAY 0.041 IL2RA IL2 FRAP1
TELOMERASEPATHWAY 0.043 IL2 EGF FRAP1 NBN
  1. Significantly pooling driver genes that were associated to over-expressed pathways, we found 14 pathways applying Fisher’s exact test (P < 0.05). Analogously, we observed 12 pathways enriched with driver genes that were associated to under-expressed pathways. We annotated all pathways with their corresponding driver genes.