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Table 1 Correlations of plasma adiponectin with the other MetS phenotypes in our cohort

From: A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation

 

Phenotype

Correlation p-value

Inter-correlation (ρ)

Body composition

Weight, kg

7.37×10-17

−0.29

Height, cm

0.030

−0.08

BMI, kg/m2

4.22×10-16

−0.29

Waist circumference (WC), cm

1.90×10-22

−0.34

Hip circumference (HC), cm

4.80×10-16

−0.29

Waist to Hip ratio (WHR)

0.000025

−0.15

Total Fat Mass (Fatkg), kg

0.00078

−0.17

Total Fat Mass (Fatpct),%

0.032

−0.11

Total Lean Mass (Leankg), kg

0.00013

−0.20

Total Lean Mass (Leanpct), %

0.026

0.11

Subcutaneous Fat (SubQF), g

0.0012

−0.18

Visceral Fat (VF), g

2.04×10-8

−0.30

Total Abdominal Fat (TAF), g

0.000039

−0.23

Respiratory Quotient (RQ)

0.78

0.02

Resting Energy Expenditure (REE), kcal/24 hrs

8.15×10-7

−0.26

REE/weight, kcal/24hrs/kg

0.29

0.06

 

REE/Lean mass (REE/LM), kcal/24hrs/kg

0.16

−0.08

Insulin responsiveness

Fasting Glucose (FG), mmol/l

0.00078

−0.12

Fasting Insulin (FI),pmol/l

8.85×10-8

−0.18

Insulin/glucose (IGR)

6.63×10-6

−0.15

Homeostasis model assessment (HOMA)

3.40×10-8

−0.19

Insulin Sensitivity (SI), (× 10-4/min/μU/ml)

1.28×10-6

0.26

Glucose Effectiveness (SG), min-1

0.068

0.10

Acute Insulin Response to glucose (AIRG), μU/ml × 10min

0.45

−0.04

 

Disposition Index (DI), AUC (Insulin0-10 min) × SI

0.012

0.14

Lipids/lipoprotein profiles

Triglycerides (TG), mmol/l

1.30×10-8

−0.20

Total Cholesterol (TC), mmol/l

0.50

−0.02

LDL-cholesterol (LDL-c), mmol/l

0.42

−0.03

Calculated LDL-C (cal. LDL-c), mmol/l

0.92

0.00

HDL-cholesterol (HDL-c), mmol/l

5.17×10-12

0.25

HMED, nm

0.000020

0.18

LMEDn, nm

0.000851

0.14

LDLppd, nm

4.43×10-6

0.19

 

BMED, nm

0.058

0.08

Cardiovascular performance

Systolic Blood Pressure (sBP), mmHg

1.55×10-6

−0.16

Diastolic Blood Pressure (dBP), mmHg

0.0071

−0.09

 

Pulse, beats/min

0.023

−0.08

Adipokine and cytokines

Leptin, ng/ml

5.64×10-11

−0.23

TNF-alpha, pg/ml

0.24

0.04

Interleukin-1 beta (IL-1β), pg/ml

0.89

0.01

 

Interleukin-6 (IL-6), pg/ml

0.81

−0.01

  1. The pair-wise intercorrelation (ρ) and its respective significance (p-value) between plasma adiponectin levels and each of the other MetS phenotypes are shown. Inter-correlations that passed the nominal significance cutoff (p<0.05) are depicted in bold italic.