Interactions of significant functional genes with HIV-1 proteins. Filled circles represent genes involved in significant functional categories. Red represents genes in profiles “Pdown”, “Bup” and “PdownBup”, while green represents genes in profiles “Pup”, “Bdown” and “PupBdown”. Unfilled squares represent HIV-1 proteins. A: Overall interactions of significant functional genes with HIV-1 proteins; B: Functional categories of known gene interaction with HIV-1.