From: Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage
 | SiHa [pmol/10e6 cells] | HeLa [pmol/10e6 cells] | HaCaT [pmol/10e6 cells] | PHKs [pmol/10e6 cells] |
---|---|---|---|---|
Methanol-soluble fraction | Â | Â | Â | Â |
CDV | 4.55 ± 0.03 | 3.20 ± 0.25 | 1.76 ± 0.11 | 4.62 ± 0.63 |
CDVp | 2.35 ± 0.13 | 1.61 ± 0.04 | 0.38 ± 0.08 | 0.78 ± 0.14 |
CDVpp | 3.50 ± 0.02 | 2.93 ± 0.08 | 1.56 ± 0.01 | 3.56 ± 0.28 |
CDVp-choline | 11.90 ± 0.37 | 8.73 ± 0.24 | 2.65 ± 0.12 | 9.18 ± 1.34 |
Sum of all metabolites | 22.29 ± 0.23 | 16.47 ± 0.06 | 6.34 ± 0.08 | 18.13 ± 2.39 |
Digestion of methanol- insoluble fraction | Â | Â | Â | Â |
Incorporated CDV | 18.39 ± 0.54 | 13.17 ± 1.43 | 8.62 ± 1.11 | 1.96 ± 0.71 |