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Table 4 The top 25 embryonic structure gene sets

From: Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

Embryonic structure

p-value

WEC effect

neural plate and or tube

1.5e-07

Posterior neuropore open

second branchial arch structure

4.9e-06

Branchial bars deformed

fourth branchial arch structure

4.9e-06

Branchial bars deformed

entire fourth branchial arch

4.9e-06

Branchial bars deformed

structure of first pharyngeal pouch

6.3e-06

Otic vesicles deformed

entire first pharyngeal pouch

6.3e-06

Otic vesicles deformed

entire neural tube

6.4e-06

Posterior neuropore open

Branchial Region

7.3e-06

Branchial bars deformed

entire second branchial arch

7.3e-06

Branchial bars deformed

structure of tympanic annulus

7.3e-06

Otic vesicles deformed

entire tympanic annulus

7.3e-06

Otic vesicles deformed

Neuroectoderm

7.5e-06

Posterior neuropore open

entire cloacal membrane

9.8e-06

No corresponding scoring parameter available in the WEC.

branchial arch structure

1.1e-05

Branchial bars deformed

structure of cloacal membrane

1.1e-05

No corresponding scoring parameter available in the WEC.

entire ostium secundum

1.1e-05

Heart ventrally turned

structure of third aortic arch

1.1e-05

Heart ventrally turned

entire branchial arch

2.2e-05

Branchial bars deformed

Otic Vesicle

2.2e-05

Otic vesicles deformed

entire auditory vesicle

2.2e-05

Otic vesicles deformed

structure of embryo stage 6

2.2e-05

No corresponding scoring parameter available in the WEC.

structure of early somite stage

2.2e-05

Somites irregular

entire early somite stage

2.2e-05

Somites irregular

third branchial arch structure

2.2e-05

Branchial bars deformed

entire third branchial arch

2.2e-05

Branchial bars deformed

  1. False discovery rate-corrected p-values for the top 25 embryonic structure gene sets from the weighted global test on triazole gene expression data from the embryonic stem cell test, together with the effect seen in rat postimplantation Whole Embryo Culture (WEC).