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Table 1 Selected E2-induced splicing events

From: Interplay between estrogen receptor and AKT in Estradiol-induced alternative splicing

Gene name

Reference

Variant

Splicing event

Long form

p value

Fold change with E2

Caspase 7, apoptosis-related cysteine protease (CASP7), transcript variant beta,

NM_033340

BM459840

ASA

R

0.000

2.01

BG339524

ES

R

0.000

2.20

BX458514

ES

R

0.000

1.96

AU131461

ASD

R

0.000

2.21

BX443602

ASD

V

0.000

2.18

Axin 1 (AXIN1), transcript variant 1

NM_003502

AA954457

ES

R

0.000

1.48

BU500157

ES

R

0.000

1.48

Cyclin E1 (CCNE1), transcript variant 1

NM_001238

BG395682

ES

R

0.000

1.41

CR601172

IR

V

0.000

1.57

BE887210

ES

R

0.001

1.41

Homeodomain interacting protein kinase 2 (HIPK2)

NM_022740

AF326592

ASA

R

0.000

1.36

Tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A, FN14)

NM_016639

BC064377

ES

R

0.000

-1.4

Tumor necrosis factor receptor superfamily, member 10A (TNFRSF10A)

NM_003844

BI029612

ASD

R

0.001

-2.01

Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (ID1), transcript variant 2

NM_181353

AI767705

PIED

R

0.000

-2.52

BP261920

PIED

R

0.000

-2.71

Tumor necrosis factor receptor superfamily, member 6 (TNFRSF6), transcript variant 1 (FAS)

NM_000043

NM_152876

ES

R

0.000

1.14

Tumor necrosis factor receptor superfamily, member 6 (TNFRSF6), transcript variant 1 (FAS)

NM_000043

NM_152874

ES

R

0.001

-1.36

Ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) (UBE1C), transcript variant 1

NM_003968

AV716795

ASA

R

0.000

3.85

  1. Reference and variant transcripts with accession number in the array are shown. Longer version of the transcript in the array (reference or the variant) is also indicated. Positive number in fold change column indicates E2-induced splicing generating higher levels of the variant whereas negative number indicates repression of splicing event leading to generation of the variant. ASA, alternative splice acceptor; ASD; Alternative splice donor; ES, exon skipping; IR, intron retention; PEID, partial internal exon deletion. Additional splicing events including novel exons (NE) are in Additional file 1, Additional file 2, Additional file 3.