Figure 2From: Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways Cell growth, cell cycle and apoptosis in SCA28 LCLs. (A) Using the MTT assay, SCA28 LCLs displayed a reduced growth compared to controls (p < 0.001). (B) FACS analysis revealed that patients’ LCLs showed an increased number of cells in G0/G1 phase (> 15%) compared to control LCLs at any time point considered. (C) AnnexinV/PI FACS analysis showed that 41 ± 4.2% of SCA28 cells were viable, vs. 61 ± 3.6% of control cells (One-tailed Student’s t-test, p = 0.003).Back to article page