From: Alteration of human blood cell transcriptome in uremia
Discovery cohort | Validation cohort | ||||
---|---|---|---|---|---|
Symbol | Gene Title | qFDR | Fold change uremia vs normal | qFDR | Fold change uremia vs normal |
Under-repesented | |||||
ATP2A3 | ATPase, Ca++ transporting, ubiquitous | 1.90E-20 | -2.67 | 1.73E-13 | -3.32 |
MESDC1 | mesoderm development candidate 1 | 6.41E-18 | -2.01 | 3.66E-11 | -2.03 |
FBRSL1 | fibrosin-like 1 | 8.79E-18 | -2.15 | 4.34E-14 | -2.63 |
RNF19B | ring finger protein 19B | 6.82E-17 | -2.48 | 2.35E-14 | -3.52 |
ATPIF1 | ATPase inhibitory factor 1 | 2.92E-16 | -2.54 | 5.36E-09 | -2.39 |
FKBP1A | FK506 binding protein 1A, 12kDa | 4.40E-16 | -2.19 | 4.45E-11 | -2.58 |
ILF3 | interleukin enhancer binding factor 3, 90kDa | 7.46E-16 | -2.07 | 2.46E-10 | -2.84 |
RBBP4 | retinoblastoma binding protein 4 | 7.63E-16 | -3.30 | 2.53E-11 | -4.31 |
PEBP1 | phosphatidylethanolamine binding protein 1 | 7.63E-16 | -2.38 | 4.01E-09 | -2.40 |
CTBP1 | C-terminal binding protein 1 | 1.26E-15 | -3.11 | 9.65E-11 | -3.92 |
HINT1 | histidine triad nucleotide binding protein 1 | 1.46E-15 | -2.71 | 1.05E-13 | -3.17 |
KLHL24 | kelch-like 24 (Drosophila) | 2.41E-15 | -3.69 | 5.34E-12 | -4.60 |
ILF3 | interleukin enhancer binding factor 3, 90kDa | 2.58E-15 | -2.56 | 6.41E-11 | -2.92 |
KDM1B | lysine (K)-specific demethylase 1B | 3.66E-15 | -2.76 | 8.63E-09 | -3.06 |
MTA1 | metastasis associated 1 | 4.91E-15 | -2.87 | 4.62E-14 | -3.80 |
KCTD5 | potassium channel tetramerisation domain containing 5 | 6.35E-15 | -2.19 | 2.57E-09 | -2.36 |
CCDC115 | coiled-coil domain containing 115 | 1.23E-14 | -2.15 | 5.87E-09 | -2.51 |
SLC23A2 | solute carrier family 23 (nucleobase transporters), member 2 | 1.42E-14 | -2.02 | 2.02E-08 | -1.94 |
ACAD8 | acyl-CoA dehydrogenase family, member 8 | 1.67E-14 | -2.37 | 1.83E-09 | -2.80 |
RAB11FIP4 | RAB11 family interacting protein 4 (class II) | 1.76E-14 | -2.40 | 3.87E-16 | -4.25 |
RNF19B | ring finger protein 19B | 1.80E-14 | -2.47 | 7.16E-12 | -3.17 |
NONO | non-POU domain containing, octamer-binding | 2.60E-14 | -2.09 | 3.78E-13 | -2.64 |
TNRC6A | trinucleotide repeat containing 6A | 3.10E-14 | -2.07 | 1.04E-14 | -2.94 |
NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 3.33E-14 | -2.29 | 8.30E-14 | -2.77 |
OGT | O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polyp | 4.75E-14 | -3.93 | 2.10E-11 | -4.57 |
ATP5C1 | ATP synthase, H + transporting, mitochondrial F1 complex, gamma polypeptide 1 | 4.50E-14 | -2.20 | 1.53E-09 | -2.33 |
MARCH5 | membrane-associated ring finger (C3HC4) 5 | 9.53E-14 | -2.01 | 3.16E-07 | -2.11 |
PPP1R8 | protein phosphatase 1, regulatory (inhibitor) subunit 8 | 1.02E-13 | -2.21 | 4.88E-08 | -2.23 |
RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 1.21E-13 | -2.30 | 2.45E-09 | -2.08 |
IRF2 | interferon regulatory factor 2 | 1.49E-13 | -2.20 | 1.94E-08 | -2.47 |
ESYT2 | extended synaptotagmin-like protein 2 | 1.54E-13 | -2.38 | 4.12E-09 | -2.71 |
BHLHE40 | basic helix-loop-helix family, member e40 | 1.64E-13 | -2.49 | 5.93E-09 | -3.17 |
RABGAP1 | RAB GTPase activating protein 1 | 1.69E-13 | -2.06 | 3.77E-09 | -2.25 |
GABPB2 | GA binding protein transcription factor, beta subunit 2 | 2.09E-13 | -2.15 | 6.64E-10 | -2.31 |
QKI | quaking homolog, KH domain RNA binding (mouse) | 2.27E-13 | -2.39 | 2.00E-08 | -2.39 |
FLI1 | Friend leukemia virus integration 1 | 2.37E-13 | -3.81 | 1.29E-11 | -7.39 |
RAB7A | RAB7A, member RAS oncogene family | 2.46E-13 | -2.24 | 1.40E-09 | -2.78 |
PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 2.52E-13 | -3.69 | 1.01E-10 | -4.69 |
BCL9L | B-cell CLL/lymphoma 9-like | 2.52E-13 | -2.02 | 8.78E-10 | -2.14 |
RNF166 | ring finger protein 166 | 2.66E-13 | -2.42 | 9.07E-10 | -2.55 |
ACTL6A | actin-like 6A | 2.77E-13 | -2.76 | 1.04E-08 | -2.90 |
S1PR1 | sphingosine-1-phosphate receptor 1 | 3.22E-13 | -2.33 | 7.38E-10 | -2.49 |
GLUD1 | glutamate dehydrogenase 1 | 3.35E-13 | -2.24 | 1.06E-09 | -2.36 |
C7orf64 | chromosome 7 open reading frame 64 | 3.35E-13 | -2.68 | 3.61E-13 | -4.25 |
CCDC88C | coiled-coil domain containing 88C | 3.36E-13 | -2.27 | 6.82E-09 | -2.17 |
CSAD | cysteine sulfinic acid decarboxylase | 3.73E-13 | -2.33 | 1.27E-11 | -2.94 |
ADSS | adenylosuccinate synthase | 4.02E-13 | -2.80 | 2.72E-11 | -4.46 |
SRSF1 | serine/arginine-rich splicing factor 1 | 4.48E-13 | -3.09 | 6.01E-10 | -3.51 |
LOC93622 | hypothetical LOC93622 | 4.87E-13 | -2.28 | 1.31E-07 | -2.63 |
ACLY | ATP citrate lyase | 5.37E-13 | -2.01 | 4.00E-10 | -2.69 |
PRF1 | perforin 1 (pore forming protein) | 5.40E-13 | -2.18 | 1.79E-10 | -3.28 |
MAPK9 | mitogen-activated protein kinase 9 | 6.36E-13 | -2.64 | 3.61E-07 | -2.46 |
KLF7 | Kruppel-like factor 7 (ubiquitous) | 8.27E-13 | -2.01 | 4.73E-09 | -2.68 |
PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 | 8.63E-13 | -2.08 | 1.98E-11 | -2.38 |
TRIB2 | tribbles homolog 2 (Drosophila) | 9.60E-13 | -2.35 | 8.64E-08 | -2.67 |
Over-represented | |||||
MORN1 | MORN repeat containing 1 | 5.75E-17 | 2.15 | 2.23E-14 | 2.92 |
FGF18 | fibroblast growth factor 18 | 5.92E-17 | 2.55 | 1.73E-11 | 2.76 |
C14orf45 | chromosome 14 open reading frame 45 | 1.59E-16 | 2.11 | 7.17E-13 | 2.69 |
ZNF205 | zinc finger protein 205 | 7.63E-16 | 2.09 | 1.44E-14 | 3.99 |
ADARB1 | adenosine deaminase, RNA-specific, B1 | 8.38E-16 | 2.20 | 1.24E-12 | 2.87 |
GLTSCR2 | glioma tumor suppressor candidate region gene 2 | 8.95E-16 | 2.37 | 2.72E-12 | 3.12 |
SAP30L | SAP30-like | 9.54E-16 | 2.98 | 1.28E-11 | 3.85 |
ODF3B | outer dense fiber of sperm tails 3B | 1.07E-15 | 2.22 | 3.72E-12 | 2.57 |
SRCRB4D | scavenger receptor cysteine rich domain containing, group B (4 domains) | 1.14E-15 | 2.16 | 6.71E-11 | 2.38 |
TNPO2 | transportin 2 | 1.26E-15 | 2.20 | 1.19E-11 | 2.68 |
MAPRE3 | microtubule-associated protein, RP/EB family, member 3 | 2.58E-15 | 2.35 | 1.82E-11 | 2.81 |
LOC100507328 LOC100508591 | hypothetical LOC100507328 /// hypothetical LOC100508591 | 2.94E-15 | 2.14 | 1.04E-14 | 2.76 |
DUX4 | double homeobox 4 /// double homeobox 4 like 2 /// double homeobox 4 like 3 /// | 3.61E-15 | 2.41 | 9.36E-15 | 2.98 |
RUNX3 | runt-related transcription factor 3 | 3.61E-15 | 2.49 | 1.30E-12 | 2.44 |
PCGF5 | Polycomb group ring finger 5 | 3.66E-15 | 2.51 | 5.03E-15 | 3.96 |
GPR144 | G protein-coupled receptor 144 | 3.82E-15 | 2.55 | 1.61E-13 | 3.01 |
MAPK8IP2 | mitogen-activated protein kinase 8 interacting protein 2 | 5.30E-15 | 2.29 | 7.39E-13 | 2.72 |
ZFPL1 | zinc finger protein-like 1 | 1.00E-14 | 2.05 | 1.34E-13 | 3.04 |
PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | 1.52E-14 | 2.15 | 4.25E-11 | 2.45 |
ELAVL3 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) | 1.65E-14 | 2.32 | 2.97E-11 | 2.48 |
FBXO44 | F-box protein 44 | 3.33E-14 | 2.09 | 1.70E-14 | 3.02 |
UBE2J2 | ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) | 3.49E-14 | 2.13 | 9.72E-11 | 2.43 |
IL34 | interleukin 34 | 3.52E-14 | 2.11 | 1.68E-10 | 2.37 |
DKFZp761P0212 | hypothetical protein DKFZp761P0212 | 4.11E-14 | 2.24 | 6.49E-15 | 2.94 |
SLC25A37 | solute carrier family 25, member 37 | 4.75E-14 | 2.93 | 5.93E-10 | 3.17 |
SCNN1A | sodium channel, nonvoltage-gated 1 alpha | 8.43E-14 | 2.04 | 4.65E-13 | 2.60 |
SFTPC | surfactant protein C | 8.69E-14 | 2.28 | 5.61E-12 | 2.55 |
PDLIM7 | PDZ and LIM domain 7 (enigma) | 1.64E-13 | 2.10 | 5.36E-12 | 2.33 |
ARMC5 | armadillo repeat containing 5 | 2.56E-13 | 2.06 | 1.19E-14 | 2.67 |
PLEKHN1 | pleckstrin homology domain containing, family N member 1 | 2.58E-13 | 2.30 | 2.08E-14 | 3.00 |
GNAS | GNAS complex locus | 2.86E-13 | 2.27 | 1.67E-16 | 4.17 |
EPN1 | epsin 1 | 2.87E-13 | 2.00 | 6.34E-14 | 2.58 |
BCL2 | B-cell CLL/lymphoma 2 | 3.77E-13 | 2.07 | 1.67E-13 | 2.72 |
CHCHD5 | Coiled-coil-helix-coiled-coil-helix domain containing 5 | 3.91E-13 | 2.08 | 8.24E-08 | 1.91 |
TFRC | Transferrin receptor (p90, CD71) | 4.09E-13 | 2.13 | 4.14E-13 | 2.46 |
RPS11 | Ribosomal protein S11 | 4.14E-13 | 3.46 | 4.53E-17 | 7.01 |
C17orf51 | chromosome 17 open reading frame 51 | 4.14E-13 | 2.21 | 4.53E-17 | 4.13 |
LMNA | Lamin A/C | 4.18E-13 | 2.23 | 2.78E-09 | 2.34 |
CYP11B2 | cytochrome P450, family 11, subfamily B, polypeptide 2 | 4.98E-13 | 2.11 | 2.12E-13 | 3.02 |
TMEFF2 | transmembrane protein with EGF-like and two follistatin-like domains 2 | 5.64E-13 | 3.15 | 1.84E-14 | 5.71 |
GP1BB | glycoprotein Ib (platelet), beta polypeptide | 6.19E-13 | 2.49 | 1.52E-15 | 3.24 |
TRIM8 | Tripartite motif-containing 8 | 8.35E-13 | 2.00 | 2.54E-10 | 2.36 |
VRTN | vertebrae development homolog (pig) | 8.63E-13 | 2.08 | 2.22E-11 | 2.18 |