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Table 2 Most highly differentially expressed functionally defined genes in uremic subjects by comparison with normal controls

From: Alteration of human blood cell transcriptome in uremia

  

Discovery cohort

Validation cohort

Symbol

Gene Title

qFDR

Fold change uremia vs normal

qFDR

Fold change uremia vs normal

Under-repesented

     

ATP2A3

ATPase, Ca++ transporting, ubiquitous

1.90E-20

-2.67

1.73E-13

-3.32

MESDC1

mesoderm development candidate 1

6.41E-18

-2.01

3.66E-11

-2.03

FBRSL1

fibrosin-like 1

8.79E-18

-2.15

4.34E-14

-2.63

RNF19B

ring finger protein 19B

6.82E-17

-2.48

2.35E-14

-3.52

ATPIF1

ATPase inhibitory factor 1

2.92E-16

-2.54

5.36E-09

-2.39

FKBP1A

FK506 binding protein 1A, 12kDa

4.40E-16

-2.19

4.45E-11

-2.58

ILF3

interleukin enhancer binding factor 3, 90kDa

7.46E-16

-2.07

2.46E-10

-2.84

RBBP4

retinoblastoma binding protein 4

7.63E-16

-3.30

2.53E-11

-4.31

PEBP1

phosphatidylethanolamine binding protein 1

7.63E-16

-2.38

4.01E-09

-2.40

CTBP1

C-terminal binding protein 1

1.26E-15

-3.11

9.65E-11

-3.92

HINT1

histidine triad nucleotide binding protein 1

1.46E-15

-2.71

1.05E-13

-3.17

KLHL24

kelch-like 24 (Drosophila)

2.41E-15

-3.69

5.34E-12

-4.60

ILF3

interleukin enhancer binding factor 3, 90kDa

2.58E-15

-2.56

6.41E-11

-2.92

KDM1B

lysine (K)-specific demethylase 1B

3.66E-15

-2.76

8.63E-09

-3.06

MTA1

metastasis associated 1

4.91E-15

-2.87

4.62E-14

-3.80

KCTD5

potassium channel tetramerisation domain containing 5

6.35E-15

-2.19

2.57E-09

-2.36

CCDC115

coiled-coil domain containing 115

1.23E-14

-2.15

5.87E-09

-2.51

SLC23A2

solute carrier family 23 (nucleobase transporters), member 2

1.42E-14

-2.02

2.02E-08

-1.94

ACAD8

acyl-CoA dehydrogenase family, member 8

1.67E-14

-2.37

1.83E-09

-2.80

RAB11FIP4

RAB11 family interacting protein 4 (class II)

1.76E-14

-2.40

3.87E-16

-4.25

RNF19B

ring finger protein 19B

1.80E-14

-2.47

7.16E-12

-3.17

NONO

non-POU domain containing, octamer-binding

2.60E-14

-2.09

3.78E-13

-2.64

TNRC6A

trinucleotide repeat containing 6A

3.10E-14

-2.07

1.04E-14

-2.94

NDUFB8

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa

3.33E-14

-2.29

8.30E-14

-2.77

OGT

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polyp

4.75E-14

-3.93

2.10E-11

-4.57

ATP5C1

ATP synthase, H + transporting, mitochondrial F1 complex, gamma polypeptide 1

4.50E-14

-2.20

1.53E-09

-2.33

MARCH5

membrane-associated ring finger (C3HC4) 5

9.53E-14

-2.01

3.16E-07

-2.11

PPP1R8

protein phosphatase 1, regulatory (inhibitor) subunit 8

1.02E-13

-2.21

4.88E-08

-2.23

RALGAPB

Ral GTPase activating protein, beta subunit (non-catalytic)

1.21E-13

-2.30

2.45E-09

-2.08

IRF2

interferon regulatory factor 2

1.49E-13

-2.20

1.94E-08

-2.47

ESYT2

extended synaptotagmin-like protein 2

1.54E-13

-2.38

4.12E-09

-2.71

BHLHE40

basic helix-loop-helix family, member e40

1.64E-13

-2.49

5.93E-09

-3.17

RABGAP1

RAB GTPase activating protein 1

1.69E-13

-2.06

3.77E-09

-2.25

GABPB2

GA binding protein transcription factor, beta subunit 2

2.09E-13

-2.15

6.64E-10

-2.31

QKI

quaking homolog, KH domain RNA binding (mouse)

2.27E-13

-2.39

2.00E-08

-2.39

FLI1

Friend leukemia virus integration 1

2.37E-13

-3.81

1.29E-11

-7.39

RAB7A

RAB7A, member RAS oncogene family

2.46E-13

-2.24

1.40E-09

-2.78

PDCD4

programmed cell death 4 (neoplastic transformation inhibitor)

2.52E-13

-3.69

1.01E-10

-4.69

BCL9L

B-cell CLL/lymphoma 9-like

2.52E-13

-2.02

8.78E-10

-2.14

RNF166

ring finger protein 166

2.66E-13

-2.42

9.07E-10

-2.55

ACTL6A

actin-like 6A

2.77E-13

-2.76

1.04E-08

-2.90

S1PR1

sphingosine-1-phosphate receptor 1

3.22E-13

-2.33

7.38E-10

-2.49

GLUD1

glutamate dehydrogenase 1

3.35E-13

-2.24

1.06E-09

-2.36

C7orf64

chromosome 7 open reading frame 64

3.35E-13

-2.68

3.61E-13

-4.25

CCDC88C

coiled-coil domain containing 88C

3.36E-13

-2.27

6.82E-09

-2.17

CSAD

cysteine sulfinic acid decarboxylase

3.73E-13

-2.33

1.27E-11

-2.94

ADSS

adenylosuccinate synthase

4.02E-13

-2.80

2.72E-11

-4.46

SRSF1

serine/arginine-rich splicing factor 1

4.48E-13

-3.09

6.01E-10

-3.51

LOC93622

hypothetical LOC93622

4.87E-13

-2.28

1.31E-07

-2.63

ACLY

ATP citrate lyase

5.37E-13

-2.01

4.00E-10

-2.69

PRF1

perforin 1 (pore forming protein)

5.40E-13

-2.18

1.79E-10

-3.28

MAPK9

mitogen-activated protein kinase 9

6.36E-13

-2.64

3.61E-07

-2.46

KLF7

Kruppel-like factor 7 (ubiquitous)

8.27E-13

-2.01

4.73E-09

-2.68

PIK3IP1

phosphoinositide-3-kinase interacting protein 1

8.63E-13

-2.08

1.98E-11

-2.38

TRIB2

tribbles homolog 2 (Drosophila)

9.60E-13

-2.35

8.64E-08

-2.67

Over-represented

     

MORN1

MORN repeat containing 1

5.75E-17

2.15

2.23E-14

2.92

FGF18

fibroblast growth factor 18

5.92E-17

2.55

1.73E-11

2.76

C14orf45

chromosome 14 open reading frame 45

1.59E-16

2.11

7.17E-13

2.69

ZNF205

zinc finger protein 205

7.63E-16

2.09

1.44E-14

3.99

ADARB1

adenosine deaminase, RNA-specific, B1

8.38E-16

2.20

1.24E-12

2.87

GLTSCR2

glioma tumor suppressor candidate region gene 2

8.95E-16

2.37

2.72E-12

3.12

SAP30L

SAP30-like

9.54E-16

2.98

1.28E-11

3.85

ODF3B

outer dense fiber of sperm tails 3B

1.07E-15

2.22

3.72E-12

2.57

SRCRB4D

scavenger receptor cysteine rich domain containing, group B (4 domains)

1.14E-15

2.16

6.71E-11

2.38

TNPO2

transportin 2

1.26E-15

2.20

1.19E-11

2.68

MAPRE3

microtubule-associated protein, RP/EB family, member 3

2.58E-15

2.35

1.82E-11

2.81

LOC100507328 LOC100508591

hypothetical LOC100507328 /// hypothetical LOC100508591

2.94E-15

2.14

1.04E-14

2.76

DUX4

double homeobox 4 /// double homeobox 4 like 2 /// double homeobox 4 like 3 ///

3.61E-15

2.41

9.36E-15

2.98

RUNX3

runt-related transcription factor 3

3.61E-15

2.49

1.30E-12

2.44

PCGF5

Polycomb group ring finger 5

3.66E-15

2.51

5.03E-15

3.96

GPR144

G protein-coupled receptor 144

3.82E-15

2.55

1.61E-13

3.01

MAPK8IP2

mitogen-activated protein kinase 8 interacting protein 2

5.30E-15

2.29

7.39E-13

2.72

ZFPL1

zinc finger protein-like 1

1.00E-14

2.05

1.34E-13

3.04

PLEKHG5

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

1.52E-14

2.15

4.25E-11

2.45

ELAVL3

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)

1.65E-14

2.32

2.97E-11

2.48

FBXO44

F-box protein 44

3.33E-14

2.09

1.70E-14

3.02

UBE2J2

ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)

3.49E-14

2.13

9.72E-11

2.43

IL34

interleukin 34

3.52E-14

2.11

1.68E-10

2.37

DKFZp761P0212

hypothetical protein DKFZp761P0212

4.11E-14

2.24

6.49E-15

2.94

SLC25A37

solute carrier family 25, member 37

4.75E-14

2.93

5.93E-10

3.17

SCNN1A

sodium channel, nonvoltage-gated 1 alpha

8.43E-14

2.04

4.65E-13

2.60

SFTPC

surfactant protein C

8.69E-14

2.28

5.61E-12

2.55

PDLIM7

PDZ and LIM domain 7 (enigma)

1.64E-13

2.10

5.36E-12

2.33

ARMC5

armadillo repeat containing 5

2.56E-13

2.06

1.19E-14

2.67

PLEKHN1

pleckstrin homology domain containing, family N member 1

2.58E-13

2.30

2.08E-14

3.00

GNAS

GNAS complex locus

2.86E-13

2.27

1.67E-16

4.17

EPN1

epsin 1

2.87E-13

2.00

6.34E-14

2.58

BCL2

B-cell CLL/lymphoma 2

3.77E-13

2.07

1.67E-13

2.72

CHCHD5

Coiled-coil-helix-coiled-coil-helix domain containing 5

3.91E-13

2.08

8.24E-08

1.91

TFRC

Transferrin receptor (p90, CD71)

4.09E-13

2.13

4.14E-13

2.46

RPS11

Ribosomal protein S11

4.14E-13

3.46

4.53E-17

7.01

C17orf51

chromosome 17 open reading frame 51

4.14E-13

2.21

4.53E-17

4.13

LMNA

Lamin A/C

4.18E-13

2.23

2.78E-09

2.34

CYP11B2

cytochrome P450, family 11, subfamily B, polypeptide 2

4.98E-13

2.11

2.12E-13

3.02

TMEFF2

transmembrane protein with EGF-like and two follistatin-like domains 2

5.64E-13

3.15

1.84E-14

5.71

GP1BB

glycoprotein Ib (platelet), beta polypeptide

6.19E-13

2.49

1.52E-15

3.24

TRIM8

Tripartite motif-containing 8

8.35E-13

2.00

2.54E-10

2.36

VRTN

vertebrae development homolog (pig)

8.63E-13

2.08

2.22E-11

2.18

  1. Genes were selected by conjoint filter to identify those with smallest qFDR and highest FC.