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Table 7 Enriched GO categories of the up-regulated genes (p < 0.01), sorted by p-value

From: Validation of microarray data in human lymphoblasts shows a role of the ubiquitin-proteasome system and NF-kB in the pathogenesis of Down syndrome

Biological process

    GO term

N. of genes

%*

p-value

FE

Transport and localization

calcium ion transport

5

8.3

0.001

10.6

transmembrane transport

7

11.7

0.01

3.7

 

metal ion transport

6

10.0

0.016

3.9

 

localization

17

28.3

0.022

1.7

 

cation transport

6

10.0

0.032

3.3

 

transport

15

25.0

0.034

1.7

 

ion transport

7

11.7

0.035

2.8

 

establishment of localization

15

25.0

0.037

1.7

Development

cellular developmental process

14

23.3

0.002

2.5

 

anatomical structure development

17

28.3

0.004

2.0

 

cell differentiation

13

21.7

0.005

2.4

 

system development

16

26.7

0.005

2.1

 

multicellular organismal development

17

28.3

0.015

1.8

 

organ development

12

20.0

0.021

2.1

  1. FE fold enrichment, *% of genes in category.