Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia

BMC Medical Genomics

Table 2 Supervised analysis comparing CLLs with adverse vs favorable prognostic factors

NEGATIVE PROGNOSTIC FACTOR	sno/scaRNA	Alias	Cytoband	Score(d)	Fold change
IGHV unmutated	SNORA70F	U70F	2q24	−10.81	0.30
	SNORA70C	U70C	9q33	−3.58	0.87
	SNORA71C	U71C	20q11	3.54	1.23
ZAP70 pos	SNORA70F	U70F	2q24	−6.91	0.43
CD38 pos	SNORA70F	U70F	2q24	−6.67	0.41
CD38 pos	SNORA70C	U70C	9q33	−3.46	0.86
12+	SNORA70F	U70F	2q24	−3.88	0.46
	SCARNA17	mgU12-22/U4-8	18q21.1	−3.58	0.72
	SNORD59A	U59	12q13.3	3.58	1.38
	SNORA2B	ACA2B	12q13.11	3.69	1.40
	SNORD59B	U59B	12q13.3	3.89	1.43
del11	SNORA70F	U70F	2q24	−4.00	0.37
del11	SCARNA9	mgU2-19/30	11q21	−3.75	0.62
del13	SNORA16A	ACA16	1p35	−5.24	0.62
	SNORA70G	U70G	12q15	−4.98	0.80
	SNORA24	ACA24	4q26	−4.87	0.65
	SNORD38A	U38A	1p34	−4.53	0.77
	SNORA20	ACA20	6q25	−4.34	0.74
	SNORD60	U60	16p13	−4.34	0.63
	SNORD54	U54	8q12	−4.31	0.73
	SNORD50A	U50	6q14	−4.28	0.70
	SNORD45B	U45B	1p31	−4.21	0.57
	SNORD76	U76	1q25	−4.20	0.75
	SNORD34	U34	19q13	−4.14	0.75
	SCARNA7	U90	3q25	−4.08	0.79
	SNORD8	mgU6-53	14q11	−4.06	0.74
	SNORD15B	U15B	11q13	−4.02	0.73
	SNORD38B	U38B	1p34	−4.00	0.69
	SNORD59B	U59B	12q13	−3.98	0.78
	SNORD104	U104	17q23	−3.88	0.77
	SNORA68	U68	19p13	−3.76	0.79
	SCARNA10	U85	12p13	−3.68	0.76

Abbreviations: scaRNA small Cajal body-specific RNA, snoRNA small nucleolar RNA.

ISSN: 1755-8794