From: Identification of potential synthetic lethal genes to p53 using a computational biology approach
Symbol | Name | Function | Reference |
---|---|---|---|
PLK1 | polo-like kinase 1 | cell cycle regulation | |
CDK16 | cyclin-dependent kinase 16 | cell cycle regulation | [20] |
RYK | receptor-like tyrosine kinase | cellular growth and differentiation Regulation | [21] |
MTOR | mechanistic target of rapamycin (serine/threonine kinase) | cellular metabolism, growth, and proliferation Regulation | |
STK17B | serine/threonine kinase 17b | positive regulation of apoptosis | [25] |
PLK4 | polo-like kinase 4 | cell cycle regulation | |
MAST2 | microtubule associated serine/threonine kinase 2 | cellular growth and differentiation Regulation | [27] |
MAP3K4 | mitogen-activated protein kinase kinase kinase 4 | role in signal transduction cascades | [28] |
MARK2 | MAP/microtubule affinity-regulating kinase 2 | cell polarity and microtubule dynamics regulation | [29] |
CDK1 | cyclin-dependent kinase 1 | cell cycle regulation | |
NEK2 | NIMA (never in mitosis gene a)-related kinase 2 | cell cycle regulation | |
PRKCSH | protein kinase C substrate 80K-H | roles in inflammation, cell growth, signaling and death | [32] |
AURKA | aurora kinase A | cell cycle regulation | |
BUB1 | mitotic checkpoint serine/threonine kinase | cell cycle regulation | [35] |
CDC7 | cell division cycle 7 homolog (S. cerevisiae) | cell cycle regulation | [30] |
SRPK1 | SRSF protein kinase 1 | cellular growth and differentiation Regulation | [36] |
TTK | TTK protein kinase | cell cycle regulation | |
VRK1 | vaccinia related kinase 1 | cell cycle regulation |