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Table 2 The candidate genes with synthetic lethality to p53 identified in at least two different datasets

From: Identification of potential synthetic lethal genes to p53 using a computational biology approach

Symbol

Name

Function

Reference

PLK1

polo-like kinase 1

cell cycle regulation

[13–19]

CDK16

cyclin-dependent kinase 16

cell cycle regulation

[20]

RYK

receptor-like tyrosine kinase

cellular growth and differentiation Regulation

[21]

MTOR

mechanistic target of rapamycin (serine/threonine kinase)

cellular metabolism, growth, and proliferation Regulation

[22–24]

STK17B

serine/threonine kinase 17b

positive regulation of apoptosis

[25]

PLK4

polo-like kinase 4

cell cycle regulation

[17, 26]

MAST2

microtubule associated serine/threonine kinase 2

cellular growth and differentiation Regulation

[27]

MAP3K4

mitogen-activated protein kinase kinase kinase 4

role in signal transduction cascades

[28]

MARK2

MAP/microtubule affinity-regulating kinase 2

cell polarity and microtubule dynamics regulation

[29]

CDK1

cyclin-dependent kinase 1

cell cycle regulation

[13, 15–17, 30, 31]

NEK2

NIMA (never in mitosis gene a)-related kinase 2

cell cycle regulation

[14–16, 30]

PRKCSH

protein kinase C substrate 80K-H

roles in inflammation, cell growth, signaling and death

[32]

AURKA

aurora kinase A

cell cycle regulation

[33, 34]

BUB1

mitotic checkpoint serine/threonine kinase

cell cycle regulation

[35]

CDC7

cell division cycle 7 homolog (S. cerevisiae)

cell cycle regulation

[30]

SRPK1

SRSF protein kinase 1

cellular growth and differentiation Regulation

[36]

TTK

TTK protein kinase

cell cycle regulation

[14–16, 37, 38]

VRK1

vaccinia related kinase 1

cell cycle regulation

[39, 40]