Table 3 Important biological functions relevant to the genes identified
From: Identification of potential synthetic lethal genes to p53 using a computational biology approach
Category | # Molecules | Representative genes |
|---|---|---|
Post-Translational Modification | 65 | RAF1,SRPK1,EPHB2,PHKG2,MARK1,MELK,MAPK13,CDK9, SRPK2,PLK4,STK17B,EIF2AK1,CHKA,RPS6KB1,MAP3K9 |
Cell Cycle | 42 | CDK1,NEK2,PIK3CA,SRPK1,CDC7,CDK11A,CDK11B,MELK, CDK9,TTK, BRAF, SRPK2,PLK4,MTOR,CLK1 |
Cellular Development | 57 | BRAF,EPHB2,CDC7,MAP3K4,MAPK13,CDK9,RIPK2,CDK16, GNE,EIF2AK1,RPS6KB1,EPHA1,AURKA,CHKA,SIK1 |
Cellular Growth and Proliferation | 62 | MTOR,EPHB2,CDC7,MELK,MAPK13,CDK9,SRPK2,PLK4, RIPK2,STK17B,EIF2AK1,GNE,NEK2,RPS6KB1,EPHA1 |
Cell Death and Survival | 61 | TTK,SRPK1,EPHB2,CDC7,MELK,MAPK13,MAP3K4,CDK9, SRPK2,PLK4,RIPK2,STK17B,GNE,EIF2AK1,MTOR |
Cell Signaling | 28 | PLK1,SRPK1,MARK2,MARK1,MAPK13,MAP3K4,PRKCZ, IRAK1,BRAF,SRPK2,ROR2,MTOR,NEK2,CLK1,MAP3K7 |
Amino Acid Metabolism | 15 | SRPK1,EPHB2,EPHA1,ACVR1,TTK,CDK9,PHKA2,MTOR,CLK1,ABL2,PDGFRA,TLK2,CHEK2,C8orf44-SGK3/SGK3 |
Small Molecule Biochemistry | 29 | MAST2,PIK3CA,SRPK1,EPHB2,CDK16,MARK2,TTK,CDK9, PRKCZ,PHKA2,MTOR,HK2,CLK1,NTRK1,PDGFRA |
Cellular Assembly and Organization | 45 | CHEK2,PIK3CA,SRPK1,EPHB2,MARK2,CDC7,MARK1,STK35,TTK,PRKCZ,PRKCSH,BRAF,ROR2,PLK4,MTOR |
DNA Replication, Recombination, and Repair | 26 | ERBB3,PIK3CA,SRPK1,CDC7,TTK,PRKCZ,BRAF,PLK4,MTOR,NEK2,NTRK1,PDGFRA,SPHK1,CHEK2,PLK1 |
Cancer | 64 | TTK,SRPK1,EPHB2,CDC7,MARK1,MELK,MAP3K4,MAPK13,STK35,SCYL2,SRPK2,PLK4,STK17B,SCYL3,EIF2AK1 |
Cellular Function and Maintenance | 43 | PIK3CA,EPHB2,MARK2,MARK1,MAPK13,CDK9,TTK,STK35,PRKCZ,PRKCSH,BRAF,ROR2,PLK4,MTOR,PLK1 |