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Table 5 Approved or experimental compounds that target related genes

From: Identification of potential synthetic lethal genes to p53 using a computational biology approach

Gene symbol

Drug & compound name j

Status

PLK1

DB08059, DB07789, DB06963, DB06897, DB07186, BI 2536, cyclapolin 9, GW843682X, ADP, threonine, serine, pyridoxal, nocodazole, paclitaxel, phosphoserine, TAK-960

experimental

CDC7

PHA 767491 hydrochloride, BMS-863233, NMS-1116354

experimental

CDK1

flavopiridol, hymenialdisine, indirubin-3′-monoxime, olomoucine, SU9516

experimental

MTOR

rapamycin, everolimus

approved

CDK16

DB07766

experimental

PLK4

ADP, microplasmin, serine, fibrinogen, cysteine

experimental

STK17B

quercetin

experimental

TTK

DB01782

experimental

STK38

mercaptopurine

experimental

NEK2

DB07180

experimental

AURKA

Adenosine-5′-Diphosphate, phosphonothreonine, taxane, paclitaxel, serine, threonine

experimental

BUB1

cytosine, paclitaxel, nocodazole

experimental

SRPK1

gemcitabine, cisplatin, serine, arginine

experimental

PRKCSH

VU 0155069, cellobiose

experimental

PKC family (PRKCH, PRKCI, PRKCSH, PRKCZ)

bryostatin, aprinocarsen, enzastaurin, tamoxifen citrate, midostaurin, UCN-01

experimental

MARK2

glycogen

experimental

PDGFRA

imatinib, sorafenib, sunitinib, pazopanib, axitinib

approved

BRD2

PFI 1, sulfadiazine, dihydrofolate

experimental

CHEK2

DDUG

experimental

CERK

NVP 231

experimental

UCK2

DB03431, DB04272, DB02097, DB03403, DB02431, DB04005

experimental

AK2

DB01717

experimental

CHKA

choline

approved

RAF1

sorafenib

approved

CSNK2B

TMCB, TBB, ellagic acid

experimental

  1. j Gene-related drug compounds identified according to DrugBank, PharmGKB, Tocris Bioscience, HMDB, and/or Novoseek; The data were obtained from the website: http://www.genecards.org and http://www.cancer.gov/drugdictionary.