Figure 1

Genomic signatures of epigenetic pathways. A. Schematic representation of the process used to generate pathway signatures, first by virally transfecting human mammary epithelial cells and then isolating RNA for microarray analysis followed by the binary regression algorithm to generate the signature. B. Heatmaps for the epigenetic pathway signatures. In the heatmaps, each column is a sample, with GFP controls on the left, and each row is a probe. Red indicates increased expression and blue indicates low expression. C. External in silico signature validation. Publically available datasets generated by independent groups were used to validate the signatures.