Figure 3

Epigenetic pathway activation in individual breast and brain cancers. The same color scale applies to both heatmaps. In each heatmap, each column gives the pathway activation for all 5 epigenetic pathways for an individual tumor. A. The epigenetic pathway signatures were projected into a metadataset of breast cancer primary tumors. B. The epigenetic pathways were projected into gene expression microarray data from the TCGA glioblastoma project. C. Kaplan-Meier survival curves showing improved relapse free survivalwith high HDAC4 activation specific subtypes of breast cancer from the metadataset of breast cancers and decreased survival with high HDAC4 activation in proneural GBM from the TCGA.