Figure 4

EZH2 and HDAC4 activation are mutually exclusive. A. Table of Spearman correlation coefficients for all 5 epigenetic pathways in the CCLE dataset. All coefficients have p < 0.000004. B. Table of Spearman correlation coefficients for all 5 epigenetic pathways in the GSK dataset. All coefficients have p < 0.04. C. Graph of EZH2 and HDAC4 activation in the 300 CCLE samples. D. Graph of EZH2 and HDAC4 activation in the GSK cell line samples. E. Graph of EZH2 and HDAC4 activation in over 5000 primary cancers from a wide variety of cancers. There is a significant lack of cancers in the upper right quadrant, showing the rarity of coactivation of EZH2 and HDAC4. F. Graph of EZH2 and HDAC4 activation in datasets including precancers, normal tissues, benign tumors, and cell lines, showing that the inverse relationship of EZH2 and HDAC4 is not cancer specific. G. Patterns of activation of EZH2 and HDAC4 mirror intrinsic subtypes of breast cancer. H. Patterns of activation of EZH2 and HDAC4 mirror subtypes of glioblastoma.