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Figure 5 | BMC Medical Genomics

Figure 5

From: Genomic pathway analysis reveals that EZH2 and HDAC4 represent mutually exclusive epigenetic pathways across human cancers

Figure 5

Biologic correlates of the EZH2 and HDAC4 pathways. A. Copy number variations in the TCGA breast cancer samples. Each point on the x-axis is a gene. The y-axis gives the average of the log2 ratio of tumor to normal copy number. B. Copy number variations in the TCGA glioblastoma cancer samples. Each point on the x-axis is a gene. The y-axis gives the average of the log2 ratio of tumor to normal copy number. C. GSEA curves for EZH2 enriched pathways from the PI3K and MAP kinase pathways. D. GSEA curves for HDAC4 enriched pathways involved in cytokine and chemokine signaling.

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