Table 1 Network of the interactions of the miRNA target genes

Migration of Phagocytes

CCL2, CCL7, CD40, CSF1, FN1, MMP14, PLAU, PLXND1, SERPINE1, SOCS3

mir-1, mir-133, mir-143-3p, mir-145-5p, mir-23a-3p, mir-28-5p, mir-455-5p

2.627/1.05E^-2

Proliferation of Mononuclear Leukocytes

ANPEP, CD1D, CD276, CD28, CD40, CD84, CSF1, DPP4, FN1, FTL, ICOS, IL18, IL2RA, KLF4, KLRC4-KLRK1/KLRK, LILRB1, MYC, PIM1, PNP, PTPRJ, THBS1, TIGIT, TNFRSF10B, TNFRSF9, TNFSF13, ULBP2

mir-1, mir-133, mir-140-3p, mir-143-3p, mir-145-5p, mir-23a-3p, , mir-28-3p, mir-28-5p, mir29b-3p, mir-455-5p

2.612/2.66E^-6

Cell Movement of Mononuclear Leukocytes

ADAM17, CCL2, CCL7, CD28, F11R, FN1, ICOS, IL18, ITGAL, MMP14, PDGFB, PLAU, PTPRO, RGS1, SERPINE1, SOCS3, THBS1, TLR4

mir-1, mir-133, mir-140-3p, mir-143-3p, mir-145-5p, mir-23a-3p, mir-28-3p, mir-28-5p, mir-29b-3p, mir-455-5p

2.316/2.66E^-3

Cell Movement of Smooth Muscle cells

CCL2, CSF1, FN1, IL18, PLAU, PTGS2, THBS1, TRIB1

mir-1, mir-143-3p, mir-23a-3p, mir-28-5p

2.201/1.20E^-3

Differentiation of Macrophages

CDC42, CSF1, LIF, MYB, PRDM1, TLR4

mir-133, mir-140-3p, mir-145-5p, mir-23a-3p, mir-28-5p, mir-29b-3p

2.166/5.70E^-3

Stimulation of T Lymphocytes

CD28, CD40, DPP4, FN1, ICOS, IL18, KLRC4-KLRK1/KLRK1

mir-1, mir-133, mir-143-3p, mir-145-5p, mir-28-3p, mir-28-5p, mir-29-3p,

2.000/7.39E^-5

Cell Death of Vascular Endothelial Cells

BCL2L1, IL18, LRP1, MAPK1, PMAIP1, THBS1, TNFRSF10B, TNFSF15

mir-1, mir-133, mir-143-3p, mir-143-5p, mir-23a-3p, mir-28-5p,

1.811/4.47E^-3

Migration of Endothelial Cells

CCL2, COL4A1, DPP4, FN1, HOXA9, MMP14, NRP1, PDGFB, PIM1, PTGS2, SCARB1, SCG2, SERPINE1,TGFBR1,THBS1,TNFSF15

mir-1, mir-133, mir-143-3p, mir-145-5p, mir-23a-3p, mir-29b-3p

1.610/2.19E^-3

Cell Movement of Endothelial Cells

ANPEP, CCL2, CDH2, COL4A1, DPP4, FN1, HOXA9, MMP14, NRP1, PDGFB, PIM1, PTGS2, SCARB1, SCG2, SERPINE1, TGFBR1, THBS1, TNFSF15

mir-1, mir-133, mir-143-3p, mir-145-5p, mir-23a-3p, mir-29b-3p

1.606/8.83E^-4

Apoptosis of Vascular Endothelial Cells

BCL2L1, IL18, LRP1, MAPK1, PMAIP1, THBS1, TNFRSF10B

mir-1, mir-133, mir-140-3p, mir-143-3p, mir-145-5p, mir-23a-3p, mir-28-5p

1.525/1.02E^-2

Proliferation of Smooth Muscle Cells

CCL2, FOS, MAPK1, PDGFB, SERPINE1, ST8SIA1, THBS1, TLR4, TNFAIP3, TRIB1

mir-1, mir-143-3p, mir-140-3p, mir-145-5p, mir-23a-3p, mir-28-5p, mir-29b-3p, mir-455-5p

1.037/1.83E^-3

Proliferation of Endothelial Cells

CDH2, COL4A1, COL4A3, CSF1, DAB2, F11R, FN1, LPAR2, NRP1, PDGFB, PIM1, SCG2, TGFBR1, THBS1, TNFSF15

mir-1, mir-133, mir-140-3p, mir-143-3p, mir-145-5p, mir-23a-3p, mir-28-5p, mir-29b-3p

-1.600/3.16E^-3