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Figure 7 | BMC Medical Genomics

Figure 7

From: Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment

Figure 7

Undirected and weighted interaction network between core clock genes and clock controlled genes in five different states: Hunter disease (H) vs. Control (C) (H/C), Treatment at time 1 (T1) vs. C (T1/C), Treatment at time 2 (T2) vs. C (T2/C) and T1 vs. H (T1/H), T2 vs. H (T2/H). Nodes colors range from red (negative FC) to green (positive FC). Diameter of nodes is proportional to the magnitude of the FC. Thickness of edges varies with the reliability of the interaction. Overall, the network exhibits the following global topological properties: clustering coefficient = 0.293, connected components = 1, diameter = 4, radius = 2, centralization = 0.259, shortest paths = 35910 (100%), characteristic path length = 2.002, average number of neighbors = 25.484, density = 0.135 and heterogeneity = 0.498.

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