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Table 2 The top 26 closest genes subjected to other well-known topological indices (i.e., degree, betweenness, clustering coefficient and topological importance)

From: Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment

Gene Degree Gene Betweenness Gene Closeness Gene Clustcoefficient Gene Top Importance
CDK1 1.16518997973136 AEBP1 0.0391432466904165 AP2M1 24.1307228971342 CCNB1 0.667477524717011 HIF1A 2.82727459653061
ARNTL 0.62961382177992 GABARAPL1 0.0337159695650262 AEBP1 24.0044419343927 WEE1 0.327773492337581 TP53 2.2936294377538
WEE1 0.551381703183312 AP2M1 0.0322382020495228 ALAS1 23.9091457589775 EIF2B2 0.144963120091208 JUN 2.27910640635946
CLOCK 0.541276442699399 CDK2AP1 0.0315960768790957 MADD 23.610217143035 NFE2L2 0.127090889959061 AHR 2.08641066658505
ARNT 0.510341236219266 CRY1 0.0260192637551128 SCG5 23.5584599878639 PER3 0.091787769071256 MAPK3 1.99897079303812
PER2 0.470238863055953 HK1 0.020820688745217 CDK2AP1 23.5469067680977 DBP 0.0907867845842636 ARNTL 1.95211068089632
CCNA2 0.439051786404152 PCBD1 0.0200202313409861 PKM2 23.4572802663874 CRY1 0.082970740931625 BHLHE40 1.94713716381873
AHR 0.416056158700292 ALAS1 0.0183753353564674 CYP7B1 23.4449074706404 CRY2 0.0756826260846772 PPARG 1.87394548486246
PER3 0.394401965276283 PKM2 0.0179531160663236 GABARAPL1 23.3945147175824 PER2 0.071064631749534 CEBPB 1.84665878053937
JUN 0.390762193059339 ITGA5 0.0178387650085763 HK1 23.1739586467746 ADA 0.0690243684292723 FOS 1.84102240012328
CRY2 0.389512630608661 HIF1A 0.017777191362097 SLC27A1 22.8176492281657 NACA 0.0657467403759448 NFIL3 1.7612499926888
PER1 0.385914004666131 MADD 0.0159827593789858 EIF2B3 22.5884323963263 EIF2B3 0.0615477588018198 AHCY 1.75501225622585
HIF1A 0.373867980001836 PDGFRB 0.0157804459691252 CSNK1E 22.5498678271054 NPAS2 0.0601731548069088 ITGA5 1.73523600034203
FOS 0.366660049188066 EIF2B3 0.0151383207986982 CRY1 22.5300456552822 CCNA2 0.0547892603398778 GSK3B 1.73339775429975
CRY1 0.343702809331051 PRKCA 0.0145929542155957 SERPINE1 22.4848488761108 PER1 0.0515484999929679 MYC 1.72885994647542
TIMELESS 0.305749308005903 CYP7B1 0.0142762897479879 AHR 22.3586129186158 BNIP3 0.0495391099313379 EGFR 1.71329372276415
RXRA 0.262643997630735 CEBPB 0.0135198135198135 LGALS9 22.252427091889 HK1 0.0452462291589491 CDKN1A 1.70167462718295
CCNB1 0.249481205055106 SCG5 0.013159167876149 LDLR 22.1424073916989 ARNTL2 0.0431626137068269 PDGFRB 1.67570618006341
RARA 0.212303842977224 CSNK2A1 0.0129216695254431 SRF 22.1323817719809 FBXL3 0.0427148551020932 NNMT 1.67192063943735
EIF2B5 0.211018680676354 NR1D2 0.0124202841183973 SEC61G 22.1049070311325 CLOCK 0.0395097804135942 AP2M1 1.64526410912342
NPAS2 0.205625544420401 HEBP1 0.0120684347099441 CEBPB 21.999792977691 TIMELESS 0.0393934593277985 PARP1 1.63582453346807
CSNK2A1 0.195935112886188 AHR 0.0118221401240269 HSF1 21.9210101165568 BHLHE41 0.0370993928249183 CDK1 1.54911430562063
CREBBP 0.190951965351357 CSNK1E 0.0117341777719136 ITGA5 21.8931454731799 BHLHE40 0.0359260940771708 VEGFA 1.48068779917142
CSNK2B 0.186506665124637 TP53 0.0113911245986718 GLUL 21.8821482612889 ARNTL 0.0343347266280929 HDAC3 1.47924179392207
ITGA5 0.186467727050273 LDLR 0.0112151998944452 PDGFRB 21.6377733649355 CSNK2A2 0.0294553443471268 AEBP1 1.46811686042305
EIF2B3 0.171980851648026 IGFBP5 0.0108985354268373 HIF1A 21.6135335177089 CCRN4L 0.0249820497668383 CCNA2 1.45373180796276