Table 2 The top 26 closest genes subjected to other well-known topological indices (i.e., degree, betweenness, clustering coefficient and topological importance)

CDK1

1.16518997973136

AEBP1

0.0391432466904165

AP2M1

24.1307228971342

CCNB1

0.667477524717011

HIF1A

2.82727459653061

ARNTL

0.62961382177992

GABARAPL1

0.0337159695650262

AEBP1

24.0044419343927

WEE1

0.327773492337581

TP53

2.2936294377538

WEE1

0.551381703183312

AP2M1

0.0322382020495228

ALAS1

23.9091457589775

EIF2B2

0.144963120091208

JUN

2.27910640635946

CLOCK

0.541276442699399

CDK2AP1

0.0315960768790957

MADD

23.610217143035

NFE2L2

0.127090889959061

AHR

2.08641066658505

ARNT

0.510341236219266

CRY1

0.0260192637551128

SCG5

23.5584599878639

PER3

0.091787769071256

MAPK3

1.99897079303812

PER2

0.470238863055953

HK1

0.020820688745217

CDK2AP1

23.5469067680977

DBP

0.0907867845842636

ARNTL

1.95211068089632

CCNA2

0.439051786404152

PCBD1

0.0200202313409861

PKM2

23.4572802663874

CRY1

0.082970740931625

BHLHE40

1.94713716381873

AHR

0.416056158700292

ALAS1

0.0183753353564674

CYP7B1

23.4449074706404

CRY2

0.0756826260846772

PPARG

1.87394548486246

PER3

0.394401965276283

PKM2

0.0179531160663236

GABARAPL1

23.3945147175824

PER2

0.071064631749534

CEBPB

1.84665878053937

JUN

0.390762193059339

ITGA5

0.0178387650085763

HK1

23.1739586467746

ADA

0.0690243684292723

FOS

1.84102240012328

CRY2

0.389512630608661

HIF1A

0.017777191362097

SLC27A1

22.8176492281657

NACA

0.0657467403759448

NFIL3

1.7612499926888

PER1

0.385914004666131

MADD

0.0159827593789858

EIF2B3

22.5884323963263

EIF2B3

0.0615477588018198

AHCY

1.75501225622585

HIF1A

0.373867980001836

PDGFRB

0.0157804459691252

CSNK1E

22.5498678271054

NPAS2

0.0601731548069088

ITGA5

1.73523600034203

FOS

0.366660049188066

EIF2B3

0.0151383207986982

CRY1

22.5300456552822

CCNA2

0.0547892603398778

GSK3B

1.73339775429975

CRY1

0.343702809331051

PRKCA

0.0145929542155957

SERPINE1

22.4848488761108

PER1

0.0515484999929679

MYC

1.72885994647542

TIMELESS

0.305749308005903

CYP7B1

0.0142762897479879

AHR

22.3586129186158

BNIP3

0.0495391099313379

EGFR

1.71329372276415

RXRA

0.262643997630735

CEBPB

0.0135198135198135

LGALS9

22.252427091889

HK1

0.0452462291589491

CDKN1A

1.70167462718295

CCNB1

0.249481205055106

SCG5

0.013159167876149

LDLR

22.1424073916989

ARNTL2

0.0431626137068269

PDGFRB

1.67570618006341

RARA

0.212303842977224

CSNK2A1

0.0129216695254431

SRF

22.1323817719809

FBXL3

0.0427148551020932

NNMT

1.67192063943735

EIF2B5

0.211018680676354

NR1D2

0.0124202841183973

SEC61G

22.1049070311325

CLOCK

0.0395097804135942

AP2M1

1.64526410912342

NPAS2

0.205625544420401

HEBP1

0.0120684347099441

CEBPB

21.999792977691

TIMELESS

0.0393934593277985

PARP1

1.63582453346807

CSNK2A1

0.195935112886188

AHR

0.0118221401240269

HSF1

21.9210101165568

BHLHE41

0.0370993928249183

CDK1

1.54911430562063

CREBBP

0.190951965351357

CSNK1E

0.0117341777719136

ITGA5

21.8931454731799

BHLHE40

0.0359260940771708

VEGFA

1.48068779917142

CSNK2B

0.186506665124637

TP53

0.0113911245986718

GLUL

21.8821482612889

ARNTL

0.0343347266280929

HDAC3

1.47924179392207

ITGA5

0.186467727050273

LDLR

0.0112151998944452

PDGFRB

21.6377733649355

CSNK2A2

0.0294553443471268

AEBP1

1.46811686042305

EIF2B3

0.171980851648026

IGFBP5

0.0108985354268373

HIF1A

21.6135335177089

CCRN4L

0.0249820497668383

CCNA2

1.45373180796276