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Table 3 Results for the 8 genes included in the classifier and chosen for qPCR validation on FFPE samples

From: Molecular differential diagnosis of follicular thyroid carcinoma and adenoma based on gene expression profiling by using formalin-fixed paraffin-embedded tissues

Gene Signal log ratio (FTC vs. FTA) Non-corrected p-value Bonferroni-corrected p-value
  Dataset A Training dataset B Validation dataset C (FFPE) Validation dataset C (FFPE) Validation dataset C (FFPE)
ELMO1 -2.15 -2.36 -0.98 0.0075 0.0377
EMCN -1.94 -2.25 -1.17 0.0003 0.0015
ITIH5 -1.51 -1.98 -0.38 0.0443 0.2214
KCNAB1 -2.45 -3.35 -1.67 0.0020 0.0100
SLCO2A1 -1.86 -1.45 -1.23 0.0003 0.0014
LRP1B -2.15 -2.7 Insufficient amplification
CA4 -2.77 -2.92 Insufficient amplification
PLEKHG4B -1.88 -1.36 Insufficient amplification
  1. Log ratios of the 8 genes from microarray training datasets A and B, and validation dataset C (qPCR), are presented. Mann–Whitney U test results for genes validated with qPCR are in bold.