Figure 1

Biochemical characterization of mouse liver slices in exposure experiments. Liver slices were incubated for 24 hours with pre-selected concentrations of cyclosporin A (CsA) 40 μM and chlorpromazine (CPZ) 20 μM. Protein content (A), ATP content (B) and LDH leakage into medium compared to total LDH content in slices (C) were measured to assess liver slices viability. Ctr stands for control. Each point is the mean ± SD of five independent experiments (liver slices were isolated from livers of five mice) and each measurement was performed in technical duplicates. None of the measured parameters were significantly affected.