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Figure 6 | BMC Medical Genomics

Figure 6

From: Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes

Figure 6

Identification of potential biomarkers for cholestasis in PCLS. PCLS were exposed for 24 hours to model toxicants for cholestasis (cyclosporin A (CsA)-A, chlorpromazine (CPZ)-B), steatosis (amiodarone (A)-C, valproic acid (VA)-D, necrosis, isoniazid (ISND-E), paraquat (PQ)-F, and controls (ctr)). GSEA led to the identification of 73 genes for which the mRNA expression was down-regulated by both CsA and CPZ. mRNA expression values for the selected biomarkers are derived from DNA-microarrays and results are presented as heat maps of log2, median centered gene expression values. Red and green indicate expression higher or lower respectively than the average expression of all samples within the same heat map. Please note Fxr is also depicted as Nr1h4.

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