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Table 1 Overview of pathway functional categories affected by CsA and CPZ

From: Treatment of mouse liver slices with cholestatic hepatotoxicants results in down-regulation of Fxr and its target genes

Functional category Nr of pathways changed by CsA Nr of pathways changed by CPZ
Immune response 58 27
Development 53 41
Pathogenesis of obesity 23 16
Apoptosis and survival 18 6
Signal transduction 16 12
Regulation of metabolism 10 8
Cell cycle 5 0
Cell adhesion 4 8
G-protein signaling 4 2
Protein folding and processing 4 2
Chemotaxis 3 1
Cytoskeleton remodeling 3 2
DNA damage 2 0
Reproduction 1 0
  1. Pathways identified in MetaCore were grouped into functional categories according to the MetaCore classification tool (first column). The number of affected pathways within the functional categories is presented in separate columns for cyclosporin A (CsA) and chlorpromazine (CPZ). MetaCore analysis revealed a total of 204 (CsA) and 125 (CPZ) significantly altered pathways (p < 0.005). All identified pathways are presented in Additional file 6: Table S3.