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Table 5 Enriched GO categories for common impairment genes

From: Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer’s disease

Genes down-regulated with impairment in both AD and HIV

Gene Category

List Hits

List Total

Pop Hits

Pop Total

EASE score

Bonferroni

Cytoplasm

175

259

2277

4968

5.62E-13

1.40E-09

Energy pathways

26

259

128

5016

4.16E-09

1.04E-05

Mitochondrion

48

259

396

4968

3.27E-08

8.15E-05

Tricarboxylic acid cycle

10

259

20

5016

2.24E-07

5.58E-04

Transit peptide

28

217

184

4007

1.14E-06

2.85E-03

Synaptic vesicle

10

259

30

4968

1.31E-05

3.26E-02

Genes up-regulated with impairment in both AD and HIV

Cell differentiation

10

131

90

5016

4.79E-13

1.40E-09

Activator

11

105

131

4007

1.89E-03

1.00E + 00

Repeat

42

105

1051

4007

1.98E-03

1.00E + 00

Cell communication

50

131

1363

5016

5.20E-03

1.00E + 00

Regulation of transcription

32

131

762

5016

5.70E-03

1.00E + 00

Phosphorylation

26

105

582

4007

6.18E-03

1.00E + 00

  1. All genes in this list were correlated with MMSE in Blalock et al. [25] (R > 0.25), as well as with GCR in the current analysis of HIV brains (both FC and BG, R > 0.25).