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Table 7 Common genes correlated with neurocognitive impairment in AD and HIV

From: Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer’s disease

Gene probe Function* Scaled intramodule connectivity kIN/max (kIN)
Up with impairment   AD hippocampus HIV frontal cortex HIV basal ganglia
CTDSP2 Cancer 1.0 1.0 1.0
SASH1 Cancer 0.84 0.95 --
FBXW12   0.86 -- 0.79
HIPK2 Cancer 0.77 0.74 0.72
CASC3 Cancer 0.74 -- 0.74
CEP350   0.72 0.90 --
PGF Cancer 0.71 -- 0.73
HS1BP3 Neurologic 0.71 -- 0.72
Down with Impairment   AD hippocampus HIV frontal cortex HIV basal ganglia
SCG5 Neurologic 0.96 -- 0.85
VDAC1 Mitochondria 0.95 0.99 0.92
KIAA1279 Neurologic 0.93 -- 0.70
PFDN4   0.92 0.84 --
MDH1 Mitochondria 0.90 0.84 1.0
ATP5G3 Mitochondria 0.90 0.95 0.99
DYNC1I1 Neurologic 0.89 0.83 0.83
PCMT1 Neurologic 0.86 0.98 0.90
TOMM20 Mitochondria 0.86 -- 0.92
KLC1 Microtubule 0.86 0.96 --
NDFIP1   0.86 0.73 0.84
KIFAP3 Neurologic 0.85 0.87 --
THYN1   0.85 0.74 0.78
GOT1 Mitochondria 0.84 0.83 0.84
TBC1D9   0.84 0.75 0.90
UCHL1 Neurologic 0.84 0.84 0.92
ACTR10   0.84 0.88 0.85
CISD1 Mitochondria 0.83 0.83 0.75
SMAP1   0.82 0.76 --
C14orf2   0.82 0.77 0.76
PEX11B   0.81 0.93 --
SLC4A1AP   0.81 0.71 --
COPS4   0.81 0.87 0.79
ITFG1   0.80 0.84 0.76
GLOD4   0.79 -- 0.83
DNAJA2 Mitochondria 0.78 0.74 0.73
SUCLA2 Mitochondria 0.76 0.87 0.84
NDUFB6   0.76 -- 0.78
EBNA1BP2   0.76 -- 0.72
TUBA4A   0.75 -- --
HINT1 Cancer 0.75 0.86 0.80
ATP6V1E1 Mitochondria 0.74 -- 0.75
GUCY1B3   0.72 0.83 0.91
ATP5H Neurologic 0.72 0.73 --
GPI   0.70 0.75 --
BEX1 Neurologic 0.70 -- 0.72
  1. *Gene function was determined by reviewing information within the Online Mendelian Inheritance in Man database http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim.