Table 7 Common genes correlated with neurocognitive impairment in AD and HIV
Gene probe | Function* | Scaled intramodule connectivity kIN/max (kIN) | ||
|---|---|---|---|---|
Up with impairment | AD hippocampus | HIV frontal cortex | HIV basal ganglia | |
CTDSP2 | Cancer | 1.0 | 1.0 | 1.0 |
SASH1 | Cancer | 0.84 | 0.95 | -- |
FBXW12 | 0.86 | -- | 0.79 | |
HIPK2 | Cancer | 0.77 | 0.74 | 0.72 |
CASC3 | Cancer | 0.74 | -- | 0.74 |
CEP350 | 0.72 | 0.90 | -- | |
PGF | Cancer | 0.71 | -- | 0.73 |
HS1BP3 | Neurologic | 0.71 | -- | 0.72 |
Down with Impairment | AD hippocampus | HIV frontal cortex | HIV basal ganglia | |
SCG5 | Neurologic | 0.96 | -- | 0.85 |
VDAC1 | Mitochondria | 0.95 | 0.99 | 0.92 |
KIAA1279 | Neurologic | 0.93 | -- | 0.70 |
PFDN4 | 0.92 | 0.84 | -- | |
MDH1 | Mitochondria | 0.90 | 0.84 | 1.0 |
ATP5G3 | Mitochondria | 0.90 | 0.95 | 0.99 |
DYNC1I1 | Neurologic | 0.89 | 0.83 | 0.83 |
PCMT1 | Neurologic | 0.86 | 0.98 | 0.90 |
TOMM20 | Mitochondria | 0.86 | -- | 0.92 |
KLC1 | Microtubule | 0.86 | 0.96 | -- |
NDFIP1 | 0.86 | 0.73 | 0.84 | |
KIFAP3 | Neurologic | 0.85 | 0.87 | -- |
THYN1 | 0.85 | 0.74 | 0.78 | |
GOT1 | Mitochondria | 0.84 | 0.83 | 0.84 |
TBC1D9 | 0.84 | 0.75 | 0.90 | |
UCHL1 | Neurologic | 0.84 | 0.84 | 0.92 |
ACTR10 | 0.84 | 0.88 | 0.85 | |
CISD1 | Mitochondria | 0.83 | 0.83 | 0.75 |
SMAP1 | 0.82 | 0.76 | -- | |
C14orf2 | 0.82 | 0.77 | 0.76 | |
PEX11B | 0.81 | 0.93 | -- | |
SLC4A1AP | 0.81 | 0.71 | -- | |
COPS4 | 0.81 | 0.87 | 0.79 | |
ITFG1 | 0.80 | 0.84 | 0.76 | |
GLOD4 | 0.79 | -- | 0.83 | |
DNAJA2 | Mitochondria | 0.78 | 0.74 | 0.73 |
SUCLA2 | Mitochondria | 0.76 | 0.87 | 0.84 |
NDUFB6 | 0.76 | -- | 0.78 | |
EBNA1BP2 | 0.76 | -- | 0.72 | |
TUBA4A | 0.75 | -- | -- | |
HINT1 | Cancer | 0.75 | 0.86 | 0.80 |
ATP6V1E1 | Mitochondria | 0.74 | -- | 0.75 |
GUCY1B3 | 0.72 | 0.83 | 0.91 | |
ATP5H | Neurologic | 0.72 | 0.73 | -- |
GPI | 0.70 | 0.75 | -- | |
BEX1 | Neurologic | 0.70 | -- | 0.72 |