Copy number heterogeneity of Chromosome 1 in different regions of Tumor 1. Segmentation results for all eight cores are shown in the top panel; amplification in red, deletions in blue. The plots below show results for Block 1–2 Core 1 and Block 1–2 Core 2 in greater detail. Regions defined by segmentation are highlighted by solid red and blue bars as above. Small dots represent the copy number values of individual array probes, while larger dots represent smoothed data resulting from averaging results from 30 adjacent probes. The high level amplification of 1q21, encompassing SETDB1, can clearly be seen adjacent to the centromere in Core 2 of Block 1–2.