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Figure 7 | BMC Medical Genomics

Figure 7

From: Intratumoral genetic heterogeneity in metastatic melanoma is accompanied by variation in malignant behaviors

Figure 7

Functional heterogeneity between clones of LM-MEL-62. Sensitivity of LM-MEL-62 and derived clones to 20nM paclitaxel (A) and 200μM 5FU (B). Values plotted represent a ratio of the MTS absorbance of drug treated samples to vehicle treated controls. Data from Clones were compared to parental LM-MEL-62 by one-way ANOVA with Dunnett’s Multiple Comparison Test. P-value < 0.05 – *; < 0.001 – ***. C) Single cell colony formation assay to measure growth independence of LM-MEL-62 and derived clones. Clones were compared to parental LM-MEL-62 using a one-way ANOVA with Dunnett’s Multiple Comparison Test. P-value < 0.001 – ***. D) Soft-agar colony formation assays to measure anchorage independent growth and clonogenicity of LM-MEL-62 and derived clones. Clones were compared to parental LM-MEL-62 using a one-way ANOVA with Dunnett’s Multiple Comparison Test. P-value < 0.05 – *; < 0.001 – ***.

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