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Table 4 The genes showing the highest down-regulation of corpus expression in patients with corpus atrophy (ranked by regression coefficients)

From: Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker

ID Symbol Description Corpus Antrum Fold changeb Clusterc
Ba R 2 Ba R 2 Hp- Hp+ Atr
ILMN_25453 AMCase chitinase, acidic, transcript variant 1 -3.66 0.69 -0.74 0.04 93 97 2 C4
ILMN_12978 MRGPRD MAS-related GPR, member D -3.32 0.71 -0.59 -0.04 103 100 2 C4
ILMN_27134 CHRD chordin, transcript variant 2 -3.25 0.69 -0.87 0.13 69 65 3 C4
ILMN_24872 AMCase chitinase, acidic, transcript variant 2 -3.24 0.69 -0.65 0.11 37 31 1 C4
ILMN_16471 ATP4A ATPase, H+/K + exchanging, alpha polypeptide -3.03 0.87 -0.78 0.10 46 37 2 C4
ILMN_21851 AQP4 aquaporin 4, transcript variant b -2.80 0.85 -0.74 0.14 27 25 2 C4
ILMN_23805 AGXT2L1 alanine-glyoxylate aminotransferase 2-like 1 -2.77 0.93 -0.48 0.10 27 9 1 C4
ILMN_11251 PTGER3 prostaglandin E receptor 3, transcript variant 9 -2.67 0.85 -0.58 0.07 27 15 2 C4
ILMN_12353 ATP4B ATPase, H+/K + exchanging, beta polypeptide -2.60 0.70 -1.28 0.13 49 46 8 C4
ILMN_11182 FGA fibrinogen alpha chain , transcript variant alpha -2.40 0.90 -0.54 0.10 20 12 2 C4
ILMN_13882 FGB fibrinogen beta chain -2.39 0.89 -0.26 -0.03 31 3 2 C4
ILMN_17569 OGG1 8-oxoguanine DNA glycosylase, transcript variant 1b -2.34 0.66 -0.30 -0.02 17 17 1 C4
ILMN_10755 CKB creatine kinase, brain -2.29 0.88 -0.76 0.39 14 9 2 C4
ILMN_13759 GPR30 G protein-coupled receptor 30, transcript variant 1 -2.28 0.73 -0.51 0.08 19 12 2 C4
ILMN_20448 CPA2 carboxypeptidase A2 (pancreatic) -2.21 0.65 -0.38 -0.09 47 26 4 nc
ILMN_20479 SIGLEC11 sialic acid binding Ig-like lectin 11 -2.20 0.91 -0.38 0.04 13 8 1 C4
ILMN_23656 SH3GL2 SH3-domain GRB2-like 2 -2.18 0.78 -0.26 -0.07 17 12 1 C4
ILMN_28182 FLJ35258 hypothetical protein 284297 -2.18 0.76 -0.38 0.47 16 7 1 C4
ILMN_28694 CDH2 cadherin 2, type 1, N-cadherin (neuronal) -2.17 0.86 -0.20 -0.06 16 7 1 C4
ILMN_5239 FNDC5 fibronectin type III domain containing 5 -2.13 0.88 -0.37 0.29 12 4 1 C4
ILMN_19137 MFSD4 major facilitator superfamily domain containing 4 -2.09 0.86 -0.49 0.16 13 9 1 C4
ILMN_6662 TRIM50 tripartite motif-containing 50 -2.05 0.84 -0.24 -0.07 16 13 1 C4
ILMN_16766 ZNF533 zinc finger protein 533 -2.04 0.85 -0.37 0.07 12 7 1 C4
ILMN_27352 CLIC6 chloride intracellular channel 6 -2.02 0.64 -0.40 -0.05 20 11 2 nc
ILMN_4712 SERPINA5 serpin peptidase inhibitor, clade A, member 5 -2.02 0.88 -0.40 -0.09 14 1 2 C4
ILMN_15602 CLCNKA chloride channel Ka -2.01 0.88 -0.28 -0.06 14 8 1 C4
ILMN_19114 DNER delta-notch-like EGF repeat-containing transmembrane -2.01 0.86 -0.54 0.22 12 5 2 C4
  1. The goodness of fits were also reported by R 2;
  2. aRegression coefficient. Linear regression was performed along the three patient groups (Hp-, Hp + and Atr).
  3. bCorpus vs. antrum gene expression fold changes of the individual patient groups.
  4. cThe result from clustering analysis; nc = not included in clustering analysis.