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Table 1 Enrichment of ESR1 binding sites within genomic regions associated with diseases or traits from GWAS

From: Integrating multiple oestrogen receptor alpha ChIP studies: overlap with disease susceptibility regions, DNase I hypersensitivity peaks and gene expression

GWAS disease/trait All ESR1 ESR1 in ≥3 datasets ESR1 in ≥5 datasets ESR1 in ≥8 datasets ESR1 in ≥11 datasets
  O/E p O/E p O/E p O/E p O/E p
Androgen levels 1.02 0.8857 0.75 0.8063 0.67 0.9093 1.60 0.4880 4.47 0.1062
Estradiol levels 1.67 0.8659 1.21 0.7437 1.06 0.8905 1.82 0.6311 0.00 1.0000
Breast cancer 2.09 0.0002 3.21 0.0004 3.92 0.0012 5.98 0.0038 7.45 0.0012
(0.002)   (0.002)   (0.002)   (0.002)   (0.002)
Coronary artery disease 1.43 0.0002 1.69 0.0068 1.74 0.0270 1.90 0.0704 0.49 0.4322
(0.002)   (0.002)   (0.005)     
Height 1.55 0.0002 1.77 0.0002 1.87 0.0004 2.36 0.0012 2.45 0.0018
(0.002)   (0.002)   (0.002)   (0.004)   (0.004)
Male baldness 0.75 0.1652 0.42 0.1840 0.37 0.3384 0.41 0.7137 1.16 0.5043
Menopause 1.05 0.8431 0.89 0.7393 0.67 0.4668 0.59 0.5813 0.64 0.9471
Menarche 1.11 0.4504 1.20 0.5341 1.30 0.4410 1.60 0.2680 1.07 0.9173
Migraine 1.29 0.2036 1.55 0.2554 2.42 0.0618 1.32 0.6031 0.00 1.0000
Multiple sclerosis 2.98 0.0002 2.98 0.0002 3.40 0.0002 4.22 0.0008 5.97 0.0002
(0.002)   (0.002)   (0.002)   (0.002)   (0.047)
Ovarian cancer 1.79 0.0134 1.93 0.2676 2.64 0.1596 3.61 0.1564 0.00 1.0000
(0.002)         
Parkinson’s disease 1.54 0.0228 1.65 0.2158 1.62 0.3910 1.17 0.9067 1.35 0.9077
(0.002)         
Polycystic ovarian syndrome 2.42 0.0002 3.60 0.0038 2.20 0.3386 1.79 0.6467 3.21 0.3286
(0.002)   (0.022)       
Prostate cancer 1.82 0.0002 2.40 0.0002 2.62 0.0006 2.76 0.0168 4.47 0.0008
(0.002)   (0.002)   (0.002)   (0.002)   (0.002)
Sex hormone binding globulin levels 1.09 0.8553 0.70 0.4008 0.46 0.2856 0.29 0.3958 0.00 1.0000
Testicular cancer 1.52 0.0056 1.36 0.3218 0.57 0.7883 0.92 0.7523 2.59 0.1498
   (0.002)         
  1. Enrichment is shown by differing numbers of shared datasets. Significant enrichment is highlighted in bold and the p-value corrected for genomic location of genes is shown in parenthesis after nominally significant enrichments. O/E = observed/expected ratio.
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BMC Medical Genomics

ISSN: 1755-8794

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