GWAS disease/trait
|
All ESR1
|
ESR1 in ≥3 datasets
|
ESR1 in ≥5 datasets
|
ESR1 in ≥8 datasets
|
ESR1 in ≥11 datasets
|
---|
|
O/E
|
p
|
O/E
|
p
|
O/E
|
p
|
O/E
|
p
|
O/E
|
p
|
Androgen levels
|
1.02
|
0.8857
|
0.75
|
0.8063
|
0.67
|
0.9093
|
1.60
|
0.4880
|
4.47
|
0.1062
|
Estradiol levels
|
1.67
|
0.8659
|
1.21
|
0.7437
|
1.06
|
0.8905
|
1.82
|
0.6311
|
0.00
|
1.0000
|
Breast cancer
|
2.09
|
0.0002
|
3.21
|
0.0004
|
3.92
|
0.0012
|
5.98
|
0.0038
|
7.45
|
0.0012
|
(0.002)
| |
(0.002)
| |
(0.002)
| |
(0.002)
| |
(0.002)
|
Coronary artery disease
|
1.43
|
0.0002
|
1.69
|
0.0068
|
1.74
|
0.0270
|
1.90
|
0.0704
|
0.49
|
0.4322
|
(0.002)
| |
(0.002)
| |
(0.005)
| | | | |
Height
|
1.55
|
0.0002
|
1.77
|
0.0002
|
1.87
|
0.0004
|
2.36
|
0.0012
|
2.45
|
0.0018
|
(0.002)
| |
(0.002)
| |
(0.002)
| |
(0.004)
| |
(0.004)
|
Male baldness
|
0.75
|
0.1652
|
0.42
|
0.1840
|
0.37
|
0.3384
|
0.41
|
0.7137
|
1.16
|
0.5043
|
Menopause
|
1.05
|
0.8431
|
0.89
|
0.7393
|
0.67
|
0.4668
|
0.59
|
0.5813
|
0.64
|
0.9471
|
Menarche
|
1.11
|
0.4504
|
1.20
|
0.5341
|
1.30
|
0.4410
|
1.60
|
0.2680
|
1.07
|
0.9173
|
Migraine
|
1.29
|
0.2036
|
1.55
|
0.2554
|
2.42
|
0.0618
|
1.32
|
0.6031
|
0.00
|
1.0000
|
Multiple sclerosis
|
2.98
|
0.0002
|
2.98
|
0.0002
|
3.40
|
0.0002
|
4.22
|
0.0008
|
5.97
|
0.0002
|
(0.002)
| |
(0.002)
| |
(0.002)
| |
(0.002)
| |
(0.047)
|
Ovarian cancer
|
1.79
|
0.0134
|
1.93
|
0.2676
|
2.64
|
0.1596
|
3.61
|
0.1564
|
0.00
|
1.0000
|
(0.002)
| | | | | | | | |
Parkinson’s disease
|
1.54
|
0.0228
|
1.65
|
0.2158
|
1.62
|
0.3910
|
1.17
|
0.9067
|
1.35
|
0.9077
|
(0.002)
| | | | | | | | |
Polycystic ovarian syndrome
|
2.42
|
0.0002
|
3.60
|
0.0038
|
2.20
|
0.3386
|
1.79
|
0.6467
|
3.21
|
0.3286
|
(0.002)
| |
(0.022)
| | | | | | |
Prostate cancer
|
1.82
|
0.0002
|
2.40
|
0.0002
|
2.62
|
0.0006
|
2.76
|
0.0168
|
4.47
|
0.0008
|
(0.002)
| |
(0.002)
| |
(0.002)
| |
(0.002)
| |
(0.002)
|
Sex hormone binding globulin levels
|
1.09
|
0.8553
|
0.70
|
0.4008
|
0.46
|
0.2856
|
0.29
|
0.3958
|
0.00
|
1.0000
|
Testicular cancer
|
1.52
|
0.0056
|
1.36
|
0.3218
|
0.57
|
0.7883
|
0.92
|
0.7523
|
2.59
|
0.1498
|
| |
(0.002)
| | | | | | | | |
- Enrichment is shown by differing numbers of shared datasets. Significant enrichment is highlighted in bold and the p-value corrected for genomic location of genes is shown in parenthesis after nominally significant enrichments. O/E = observed/expected ratio.