GWAS disease/trait | All ESR1 | ESR1 in ≥3 datasets | ESR1 in ≥5 datasets | ESR1 in ≥8 datasets | ESR1 in ≥11 datasets | |||||
---|---|---|---|---|---|---|---|---|---|---|
 | O/E | p | O/E | p | O/E | p | O/E | p | O/E | p |
Androgen levels | 1.02 | 0.8857 | 0.75 | 0.8063 | 0.67 | 0.9093 | 1.60 | 0.4880 | 4.47 | 0.1062 |
Estradiol levels | 1.67 | 0.8659 | 1.21 | 0.7437 | 1.06 | 0.8905 | 1.82 | 0.6311 | 0.00 | 1.0000 |
Breast cancer | 2.09 | 0.0002 | 3.21 | 0.0004 | 3.92 | 0.0012 | 5.98 | 0.0038 | 7.45 | 0.0012 |
(0.002) | Â | (0.002) | Â | (0.002) | Â | (0.002) | Â | (0.002) | ||
Coronary artery disease | 1.43 | 0.0002 | 1.69 | 0.0068 | 1.74 | 0.0270 | 1.90 | 0.0704 | 0.49 | 0.4322 |
(0.002) | Â | (0.002) | Â | (0.005) | Â | Â | Â | Â | ||
Height | 1.55 | 0.0002 | 1.77 | 0.0002 | 1.87 | 0.0004 | 2.36 | 0.0012 | 2.45 | 0.0018 |
(0.002) | Â | (0.002) | Â | (0.002) | Â | (0.004) | Â | (0.004) | ||
Male baldness | 0.75 | 0.1652 | 0.42 | 0.1840 | 0.37 | 0.3384 | 0.41 | 0.7137 | 1.16 | 0.5043 |
Menopause | 1.05 | 0.8431 | 0.89 | 0.7393 | 0.67 | 0.4668 | 0.59 | 0.5813 | 0.64 | 0.9471 |
Menarche | 1.11 | 0.4504 | 1.20 | 0.5341 | 1.30 | 0.4410 | 1.60 | 0.2680 | 1.07 | 0.9173 |
Migraine | 1.29 | 0.2036 | 1.55 | 0.2554 | 2.42 | 0.0618 | 1.32 | 0.6031 | 0.00 | 1.0000 |
Multiple sclerosis | 2.98 | 0.0002 | 2.98 | 0.0002 | 3.40 | 0.0002 | 4.22 | 0.0008 | 5.97 | 0.0002 |
(0.002) | Â | (0.002) | Â | (0.002) | Â | (0.002) | Â | (0.047) | ||
Ovarian cancer | 1.79 | 0.0134 | 1.93 | 0.2676 | 2.64 | 0.1596 | 3.61 | 0.1564 | 0.00 | 1.0000 |
(0.002) | Â | Â | Â | Â | Â | Â | Â | Â | ||
Parkinson’s disease | 1.54 | 0.0228 | 1.65 | 0.2158 | 1.62 | 0.3910 | 1.17 | 0.9067 | 1.35 | 0.9077 |
(0.002) | Â | Â | Â | Â | Â | Â | Â | Â | ||
Polycystic ovarian syndrome | 2.42 | 0.0002 | 3.60 | 0.0038 | 2.20 | 0.3386 | 1.79 | 0.6467 | 3.21 | 0.3286 |
(0.002) | Â | (0.022) | Â | Â | Â | Â | Â | Â | ||
Prostate cancer | 1.82 | 0.0002 | 2.40 | 0.0002 | 2.62 | 0.0006 | 2.76 | 0.0168 | 4.47 | 0.0008 |
(0.002) | Â | (0.002) | Â | (0.002) | Â | (0.002) | Â | (0.002) | ||
Sex hormone binding globulin levels | 1.09 | 0.8553 | 0.70 | 0.4008 | 0.46 | 0.2856 | 0.29 | 0.3958 | 0.00 | 1.0000 |
Testicular cancer | 1.52 | 0.0056 | 1.36 | 0.3218 | 0.57 | 0.7883 | 0.92 | 0.7523 | 2.59 | 0.1498 |
 |  | (0.002) |  |  |  |  |  |  |  |  |