Integrating multiple oestrogen receptor alpha ChIP studies: overlap with disease susceptibility regions, DNase I hypersensitivity peaks and gene expression

Adam E Handel; Geir K Sandve; Giulio Disanto; Lahiru Handunnetthi; Gavin Giovannoni; Sreeram V Ramagopalan

doi:10.1186/1755-8794-6-45

Table 1 Enrichment of ESR1 binding sites within genomic regions associated with diseases or traits from GWAS

From: Integrating multiple oestrogen receptor alpha ChIP studies: overlap with disease susceptibility regions, DNase I hypersensitivity peaks and gene expression

GWAS disease/trait	All ESR1		ESR1 in ≥3 datasets		ESR1 in ≥5 datasets		ESR1 in ≥8 datasets		ESR1 in ≥11 datasets
	O/E	p	O/E	p	O/E	p	O/E	p	O/E	p
Androgen levels	1.02	0.8857	0.75	0.8063	0.67	0.9093	1.60	0.4880	4.47	0.1062
Estradiol levels	1.67	0.8659	1.21	0.7437	1.06	0.8905	1.82	0.6311	0.00	1.0000
Breast cancer	2.09	0.0002	3.21	0.0004	3.92	0.0012	5.98	0.0038	7.45	0.0012
Breast cancer	2.09	(0.002)		(0.002)		(0.002)		(0.002)		(0.002)
Coronary artery disease	1.43	0.0002	1.69	0.0068	1.74	0.0270	1.90	0.0704	0.49	0.4322
Coronary artery disease	1.43	(0.002)		(0.002)		(0.005)
Height	1.55	0.0002	1.77	0.0002	1.87	0.0004	2.36	0.0012	2.45	0.0018
Height	1.55	(0.002)		(0.002)		(0.002)		(0.004)		(0.004)
Male baldness	0.75	0.1652	0.42	0.1840	0.37	0.3384	0.41	0.7137	1.16	0.5043
Menopause	1.05	0.8431	0.89	0.7393	0.67	0.4668	0.59	0.5813	0.64	0.9471
Menarche	1.11	0.4504	1.20	0.5341	1.30	0.4410	1.60	0.2680	1.07	0.9173
Migraine	1.29	0.2036	1.55	0.2554	2.42	0.0618	1.32	0.6031	0.00	1.0000
Multiple sclerosis	2.98	0.0002	2.98	0.0002	3.40	0.0002	4.22	0.0008	5.97	0.0002
Multiple sclerosis	2.98	(0.002)		(0.002)		(0.002)		(0.002)		(0.047)
Ovarian cancer	1.79	0.0134	1.93	0.2676	2.64	0.1596	3.61	0.1564	0.00	1.0000
Ovarian cancer	1.79	(0.002)
Parkinson’s disease	1.54	0.0228	1.65	0.2158	1.62	0.3910	1.17	0.9067	1.35	0.9077
Parkinson’s disease	1.54	(0.002)
Polycystic ovarian syndrome	2.42	0.0002	3.60	0.0038	2.20	0.3386	1.79	0.6467	3.21	0.3286
Polycystic ovarian syndrome	2.42	(0.002)		(0.022)
Prostate cancer	1.82	0.0002	2.40	0.0002	2.62	0.0006	2.76	0.0168	4.47	0.0008
Prostate cancer	1.82	(0.002)		(0.002)		(0.002)		(0.002)		(0.002)
Sex hormone binding globulin levels	1.09	0.8553	0.70	0.4008	0.46	0.2856	0.29	0.3958	0.00	1.0000
Testicular cancer	1.52	0.0056	1.36	0.3218	0.57	0.7883	0.92	0.7523	2.59	0.1498
		(0.002)

Enrichment is shown by differing numbers of shared datasets. Significant enrichment is highlighted in bold and the p-value corrected for genomic location of genes is shown in parenthesis after nominally significant enrichments. O/E = observed/expected ratio.

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