Table 2 Comparison of results from microarrays and RT-qPCR

Biomarkers in heart failure

End1

1.9

0.043

**

1.3

0.005

**

-1.1

0.412

ns

-1.3

0.147

ns

Nppa

19.2

0.001

***

3.7

1.3e-5

***

1.1

0.884

ns

1.2

0.694

ns

Nppb

2.2

0.001

***

1.4

0.14

ns

-1.1

0.849

ns

-1.5

0.496

ns

Others related to cardiac hypertrophy and left ventricular remodelling

Corin

2.6

0.020

*

1.4

3e-5

***

1

0.788

ns

1

0.934

ns

Hcn4

3.6

0.013

*

2.1

0.001

***

1

0.951

ns

-1.4

0.343

ns

Pparg

-1.7

0.017

**

-1.4

1.4e-4

***

1.1

0.643

ns

1

0.865

ns

Tgfβ1

1.4

0.071

ns

1.3

1.6e-5

***

1.1

0.613

ns

1.1

0.712

ns

Tgfβ2

3.1

0.010

**

2

7.8e-5

***

-1.1

0.762

ns

1

0.874

ns

ECM – Extracellular matrix components

ECM structural components

Col1a1

3.9

0.003

**

2.3

6.1e-6

***

1

0.767

ns

1

0.852

ns

Col1a2

2.3

0.011

**

1.6

5e-5

***

-1.1

0.685

ns

1

0.852

ns

Col3a1

2.1

0.017

**

1.5

1.3e-5

***

-1.1

0.579

ns

1.1

0.619

ns

Col8a1

5.1

0.001

***

2.1

3.1e-8

***

1

0.880

ns

1

0.390

ns

Col12a1

5.1

0.001

***

2.9

3.4e-8

***

1

0.912

ns

-1.1

0.215

ns

Col14a1

2.4

0.001

***

2

1.0e-7

***

1.1

0.628

ns

1.1

0.891

ns

Col18a1

2.2

0.001

***

1.3

7.6e-5

***

-1.1

0.668

ns

-1.1

0.310

ns

Eln

2.2

0.001

***

1.4

1.8e-5

***

1.2

0.304

ns

1.1

0.689

ns

Fn1

3.8

0.005

**

2.9

6.2e-8

***

1.2

0.384

ns

1.1

0522

ns

Lamc1

1.3

0.014

**

1.3

5.1e-7

***

1.1

0.451

ns

1

0.773

ns

Prg4

2.1

0.004

**

1.7

2.4e-5

***

1

0.907

ns

-1.1

0.430

ns

Vtn

-1.4

0.015

*

-1.4

2.3e-6

***

1

0.874

ns

-1.1

0.167

ns

Matricellular proteins

Mmp2

1.6

0.001

***

1.4

7.5e-7

***

1

0.855

ns

1.1

0.343

ns

Mmp9

2.7

0.351

ns ^†

1.73

0.037

*

1.2

0.660

ns

1

0.871

ns

Mmp13

62.2

0.001

*** ^†

2

0.021

*

-1.2

0.358

ns

1

0.862

ns

Mmp14

2.3

0.019

**

1.3

0.002

**

1.1

0.529

ns

-1.1

0.465

ns

Mmp16

2.9

0.020

**

1.3

0.006

***

-1.4

0.204

ns

-1.3

0.334

ns

Mmp23

1.8

0.027

**

1.3

1.0e-4

***

-1.1

0.572

ns

-1.2

0.438

ns

Postn

20.8

0.001

***

8

1.2e-9

***

1

0.988

ns

1.1

0.738

ns

Spp1

52.3

0.003

**

4.1

2.3e-5

***

2.7

0.157

ns

2.3

0.212

ns

Thbs4

19.4

0.003

**

6.1

8e-9

***

-1.7

0.272

ns

-1.3

0.348

ns

Timp1

3

0.008

**

2.4

2.8e-7

***

1.2

0.287

ns

1.4

0.041

*

Timp2

1.7

0.037

**

1.5

4.6e-7

***

-1.1

0.666

ns

1

0.936

ns

Timp3

1.9

0.043

*

1.2

7.8e-5

***

-1.4

0.288

ns

-1.3

0.321

ns

Timp4

-1.5

0.151

ns

-1.4

0.006

**

-1.3

0.307

ns

-1.1

0.716

ns