Database | Pathway | Bonferonni p-value | Candidate genes involved in the pathway |
---|---|---|---|
Literature-collected candidate genes | |||
KEGG | Regulation of actin cytoskeleton | 4.70E-06 | ACTB, BRAF, CDC42, CFL1, CHRM3, EZR, FGD1, FGF9, FGFR1, FGFR2, HRAS, ITGB1, KRAS, MAP2K1, MAP2K2, MYL2, MYL9, PDGFA, PFN1, PPP1CA, PPP1CB, PXN, RAC1, RAF1, RHOA, RRAS, SOS1 |
REACTOME | Muscle contraction | 5.39E-06 | DES, MYH3, MYL2, MYL3, TNNI2, TNNT2, TNNT3, TPM1, TPM3, TPM4, TTN |
KEGG | Focal adhesion | 1.05E-05 | ACTB, BRAF, CCND1, CDC42, COL1A2, COL2A1, COL5A1, FLNA, GRB2, GSK3B, HRAS, IGF1, ILK, ITGB1, MAP2K1, MYL2, MYL9, PDGFA, PPP1CA, PPP1CB, PXN, RAC1, RAF1, RHOA, SOS1, THBS4 |
REACTOME | Signaling by PDGF | 3.61E-5 | COL1A2, COL2A1, COL5A1, GRB2, HRAS, KRAS, MAP2K1, MAP2K2, PDGFA PTPN11, RAF1, SOS1, STAT3, THBS4 |
REACTOME | Signaling by insulin receptor | 7.02E-05 | EIF4E, EIF4EBP1, GRB2, HRAS, KRAS, MAP2K1, MAP2K2, RAF1, RPS6, RPS6KB1, SOS1 |
REACTOME | Signaling by EGFR | 0.0022 | CDC42, GRB2, HRAS, KRAS, MAP2K1, MAP2K2, PTPN11, PXN, RAF1, SOS1 |
PANTHER | RAS pathway | 0.0025 | BRAF, CDC42, GRB2, GSK3B, HRAS, KRAS, MAP2K1, MAP2K2, RAC1, RAF1, RHOA, RRAS, SOS1, STAT3 |
KEGG | Hypertrophic cardiomyopathy (HCM) | 0.0035 | ACTB, DES, IGF1, ITGB1, MYH7, MYL2, MYL3, TNNT2, TPM1, TPM3, TPM4, TTN |
BIOCARTA | Role of MAL in Rho-mediated activation of SRF | 0.044 | ACTA1, CDC42, MAP2K1, MAP2K2, RAC1, RAF1, RHOA |
BIOCARTA | IGF-1 signaling | 0.0067 | FOS, GRB2, HRAS, IGF1, MAP2K1, PTPN11, RAF1, SOS1 |
PANTHER | Integrin signaling | 0.0070 | BRAF, CDC42, COL1A2, COL2A1, COL5A1, FLNA, GRB2, HRAS, ILK, ITGB1, KRAS, MAP2K1, MAP2K2, PXN, RAC1, RAF1, RHOA, RND2, RRAS, SOS1 |
KEGG | Dilated cardiomyopathy | 0.0099 | ACTB, DES, IGF1, ITGB1, MYH7, MYL2, MYL3, TNNT2, TPM1, TPM3, TPM4, TTN |
Network-predicted candidate genes | |||
REACTOME | Muscle contraction | 2.71E-24 | ACTN2, DMD, MYBPC1, MYBPC2, MYBPC3, MYH8, MYL1, MYL4, NEB, TCAP, TMOD1, TNNC1, TNNC2, TNNI1, TNNI3, TNNT1, TPM2, VIM |
KEGG | Hypertrophic cardiomyopathy (HCM) | 9.68E-6 | ACTC1, DMD, MYBPC3, TGFB1, TGFB2, TGFB3, TNNC1, TNNI3, TPM2, |
PANTHER | TGF-beta signaling pathway | 1.07E-5 | BMP2, LEFTY1, LEFTY2, LOC100271831, MAPK1, MAPK3, MSTN, NODAL, TGFB1, TGFB2, TGFB3 |
KEGG | Dilated cardiomyopathy | 2.35E-5 | ACTC1, DMD, MYBPC3, TGFB1, TGFB2, TGFB3, TNNC1, TNNI3, TPM2 |