NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases

BMC Medical Genomics

Table 3 Genes that are toxicity and aggregation modifiers in D. melanogaster and their orthologs in H. sapiens and M. musculus ¹

*D. melanogaster*genes	*D. melanogaster*ND models²	Ref	*H. sapiens*orthologs	*M. musculus*orthologs	Ref³
DnaJ-1	AD_Tau, HD, PolyQ, SCA1, SCA3	[30–34]	DNAJB1, DNAJB4, DNAJB5, DNAJB13	Dnajb1, Dnajb4, Dnajb5, Dnajb13	[35–40]
thread	AD_Tau, HD, SCA1, SCA3, SCA7	[21, 32, 41, 42]	BIRC2, BIRC3	Birc2, Birc3	[43–45]
Atx2	AD_Tau, HD, SCA1, SCA3, SCA7	[21, 41, 42, 46]	Atxn2, Atxn2L	Atxn2, Atxn2L	[47–52]
Hsc70-3	HD, SCA1, SCA7	[32, 42]	HSPA5	Hspa5	[53]
Hsc70Cb	AD_Tau, HD, SCA3	[5, 54, 55]	HSPH1(HSP110), HSPA4, HSPA4L	Hsph1 (Hsp110), Hspa4, Hsp4l	[56, 57]
Rpd3	HD, SCA1, SCA7	[34, 42, 58]	HDAC1, HDAC2	Hdac1, Hdac2	[59–65]
14-3-3epsilon	HD, SCA1	[66, 67]	YWHAZ, YWHAB, YWHAE	Ywhaz, Ywhab, Ywhae	[67–73]
CG5537	HD	[74]	UPRT	Uprt	N/A
Hsf	HD, SCA3	[75]	Hsf2, Hsf4, Hsfx1, Hsfx2, Hsfy1, Hsfy2, Hsf5	Hsf2, Hsf3, Hsf4, Hsfy2, Hsf5	[76–78]
Nipped-A	HD, SCA3, SCA7	[42, 54, 55]	TRRAP	Trrap	[79, 80]
Sec61alpha	HD, SCA3	[81]	Sec61A1, Sec61A2	Sec61a1, Sec61a2	[82, 83]
Nup160	HD, SCA3	[55, 74]	Nup160	NUP160	[84–86]
CG1109	HD	[74]	WDR33(WDC146)	Wdr33 (Wdc146)	N/A
Snap	HD	[66]	NAPA, NAPB	Napa, Napb	N/A
smt3	HD	[74]	SUMO1, SUMO2, SUMO3, SUMO4	Sumo1, Sumo2, Sumo3	[87–91]
Mef2	HD	[66]	MEF2A, MEF2B, MEF2BNB, MEF2C, MEF2D	Mef2a, Mef2b, Mef2c, Mef2d	[92–97]
chic	HD	[98]	PFN4	Pfn4	[99]
Rpt1	HD	[74]	PSMC2	Psmc2	[100–102]
Sin3A	HD, SCA1, SCA3	[5, 32, 34]	Sin3A, Sin3B	Sin3a, Sin3b	[103]
Rheb	AD_Tau, HD	[74, 104]	Rheb, RhebL1	Rheb, Rhebl1	[105, 106]

¹Orthologs were obtained from NeuroGeM in which protein homolog groups of NCBI HomoloGene and InParanoid were integrated.
²Disease models in which the genes were identified as modifiers.
³Studies in which the mammalian orthologs were identified as modifiers.

ISSN: 1755-8794