Skip to main content

Table 2 List of top 5 secreted and 5 non-secreted markers

From: Integrated molecular portrait of non-small cell lung cancers

Candidate Gene name Frequency of overexpressionT vs N in AC patients (%) (p-value) Frequency of overexpression T vs N in SCC patients (%) (p-value) Chemores AUC (p-value) Bild et al.AUC (p-value)
SPP1 Secreted phosphoprotein 1 96 98 0.41 0.40
(<10-10) (<10-10) (0.70) (0.76)
CTHRC1 Collagen triple helix containing 1 96 98 0.42 0.40
(<10-10) (<10-10) (0.63) (0.75)
GREM1 Gremlin 1 88 98 0.40 0.40
(<10-10) (<10-10) (0.77) (0.78)
SPINK1 Serine peptidase inhibitor Kazal type 1 93 80 0.80 0.81
(<10-10) (1.14 × 10-7) (0.03) (0.01)
BMP7 Bone morphogenetic protein 7 34 90 0.86 0.82
(0.01) (<10-10) (0.003) (0.01)
KRT6A Keratin 6A 73 96 0.90 0.88
(9.18 × 10-5) (<10-10) (0.002) (0.002)
TP63 Tumor protein p63 39 98 0.95 0.85
(0.09) (<10-10) (<0.001) (0.01)
LGALS7 Lectin, galactoside-binding, soluble, 7 73 94 0.87 --
(9.18 × 10-5) (<10-10) (0.003) --
GCNT3 Glucosaminyl (N-acetyl) transferase 3 88 80 0.72 0.68
(<10-10) (1.14 × 10-7) (0.08) (0.10)
SPRR2D Small proline-rich protein 2D 52 96 0.84 --
(0.76) (<10-10) (0.003) --
  1. Notes: T = tumour, N = Normal; Overexpression is defined as log(T/N) > 0. P-values in the brackets are from the test that whether the frequency differs from 50%. AUC values refer to prediction of AC vs SCC. Median values of individual AUCs of the ten biomarkers in classifying histology type are computed. Monte-Carlo p-values based on 1,000 runs are indicated in the bracket. LGALS7 and SPRR2D probes were not in Bild et al. data.
  2. List of top 5 secreted (the first five entries) and 5 non-secreted markers (the second five entries) that are over-expressed in tumours compared to normal tissues.