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Table 2 List of top 5 secreted and 5 non-secreted markers

From: Integrated molecular portrait of non-small cell lung cancers

Candidate

Gene name

Frequency of overexpressionT vs N in AC patients (%) (p-value)

Frequency of overexpression T vs N in SCC patients (%) (p-value)

Chemores AUC (p-value)

Bild et al.AUC (p-value)

SPP1

Secreted phosphoprotein 1

96

98

0.41

0.40

(<10-10)

(<10-10)

(0.70)

(0.76)

CTHRC1

Collagen triple helix containing 1

96

98

0.42

0.40

(<10-10)

(<10-10)

(0.63)

(0.75)

GREM1

Gremlin 1

88

98

0.40

0.40

(<10-10)

(<10-10)

(0.77)

(0.78)

SPINK1

Serine peptidase inhibitor Kazal type 1

93

80

0.80

0.81

(<10-10)

(1.14ā€‰Ć—ā€‰10-7)

(0.03)

(0.01)

BMP7

Bone morphogenetic protein 7

34

90

0.86

0.82

(0.01)

(<10-10)

(0.003)

(0.01)

KRT6A

Keratin 6A

73

96

0.90

0.88

(9.18ā€‰Ć—ā€‰10-5)

(<10-10)

(0.002)

(0.002)

TP63

Tumor protein p63

39

98

0.95

0.85

(0.09)

(<10-10)

(<0.001)

(0.01)

LGALS7

Lectin, galactoside-binding, soluble, 7

73

94

0.87

--

(9.18ā€‰Ć—ā€‰10-5)

(<10-10)

(0.003)

--

GCNT3

Glucosaminyl (N-acetyl) transferase 3

88

80

0.72

0.68

(<10-10)

(1.14ā€‰Ć—ā€‰10-7)

(0.08)

(0.10)

SPRR2D

Small proline-rich protein 2D

52

96

0.84

--

(0.76)

(<10-10)

(0.003)

--

  1. Notes: T = tumour, N = Normal; Overexpression is defined as log(T/N)ā€‰>ā€‰0. P-values in the brackets are from the test that whether the frequency differs from 50%. AUC values refer to prediction of AC vs SCC. Median values of individual AUCs of the ten biomarkers in classifying histology type are computed. Monte-Carlo p-values based on 1,000 runs are indicated in the bracket. LGALS7 and SPRR2D probes were not in Bild et al. data.
  2. List of top 5 secreted (the first five entries) and 5 non-secreted markers (the second five entries) that are over-expressed in tumours compared to normal tissues.